PreprintArticleVersion 1Preserved in Portico This version is not peer-reviewed
Associations Between Health Behaviours, Gastrointestinal Symptoms, and Gut Microbiota in a Cross-Sectional Sample of Cancer Survivors: Secondary Analysis from the Chemo-Gut Study
Version 1
: Received: 11 March 2023 / Approved: 16 March 2023 / Online: 16 March 2023 (08:57:56 CET)
How to cite:
Deleemans, J.M.; Chleilat, F.; Reimer, R.A.; Baydoun, M.; Piedalue, K.; Lowry, D.E.; Carlson, L.E. Associations Between Health Behaviours, Gastrointestinal Symptoms, and Gut Microbiota in a Cross-Sectional Sample of Cancer Survivors: Secondary Analysis from the Chemo-Gut Study. Preprints2023, 2023030300. https://doi.org/10.20944/preprints202303.0300.v1
Deleemans, J.M.; Chleilat, F.; Reimer, R.A.; Baydoun, M.; Piedalue, K.; Lowry, D.E.; Carlson, L.E. Associations Between Health Behaviours, Gastrointestinal Symptoms, and Gut Microbiota in a Cross-Sectional Sample of Cancer Survivors: Secondary Analysis from the Chemo-Gut Study. Preprints 2023, 2023030300. https://doi.org/10.20944/preprints202303.0300.v1
Deleemans, J.M.; Chleilat, F.; Reimer, R.A.; Baydoun, M.; Piedalue, K.; Lowry, D.E.; Carlson, L.E. Associations Between Health Behaviours, Gastrointestinal Symptoms, and Gut Microbiota in a Cross-Sectional Sample of Cancer Survivors: Secondary Analysis from the Chemo-Gut Study. Preprints2023, 2023030300. https://doi.org/10.20944/preprints202303.0300.v1
APA Style
Deleemans, J.M., Chleilat, F., Reimer, R.A., Baydoun, M., Piedalue, K., Lowry, D.E., & Carlson, L.E. (2023). Associations Between Health Behaviours, Gastrointestinal Symptoms, and Gut Microbiota in a Cross-Sectional Sample of Cancer Survivors: Secondary Analysis from the Chemo-Gut Study. Preprints. https://doi.org/10.20944/preprints202303.0300.v1
Chicago/Turabian Style
Deleemans, J.M., Dana E. Lowry and Linda E. Carlson. 2023 "Associations Between Health Behaviours, Gastrointestinal Symptoms, and Gut Microbiota in a Cross-Sectional Sample of Cancer Survivors: Secondary Analysis from the Chemo-Gut Study" Preprints. https://doi.org/10.20944/preprints202303.0300.v1
Abstract
Background: Health behaviors, such as diet and exercise, are actions individuals take that can potentially impact gastrointestinal (GI) symptoms and the gut microbiota. Little is known about how health behaviours impact GI symptoms and the gut microbiota after anti-cancer therapies. Methods: This is a secondary analysis of a cross-sectional study that investigated relationships between GI symptoms, gut microbiota, and patient-reported outcomes in adult cancer survivors. Gut microbiota was assessed from stool samples using 16S rRNA gene sequencing. GI symptoms and health behaviors were measured via self-report. Descriptive statistics, linear regression, and correlation analyses are reported. Results: A total of 334 cancer survivors participated and a subsample of 17 provided stool samples. Most survivors rated their diet as moderately healthy (55.7%) and reported engaging in low intensity exercise (53.9%) for ≤5 hours/week (69.1%). Antibiotic use was associated with more belly pain, constipation, and diarrhea (p< .05). Survivors consuming a healthier diet had fewer symptoms of gas/bloating (p= 0.02). Better diet health was positively correlated with Lachnospiraceae abundance, and negatively with Bacteroides abundance (ps <.05). Greater exercise frequency positively correlated with abundance of Lachnospiraceae, Faecalibacterium, Bacteroides, Anaerostipes, Alistipes, and Subdoligranulum. (ps<.05). Conclusion: Results provide evidence for associations between dietary health behaviours and GI symptoms. Diet and exercise behaviours are related to certain types of bacteria, but the direction of causality is unknown. Dietary-based interventions may be optimally suited to address survivors’ GI symptoms by influencing the gut microbiota. Larger trials are needed.
Keywords
Health behaviors; gastrointestinal symptoms; gut microbiota; diet; exercise; cancer survivors
Subject
Medicine and Pharmacology, Oncology and Oncogenics
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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