Bruet, E.; Amarante-Silva, D.; Gorojankina, T.; Creuzet, S. The Emerging Roles of the Cephalic Neural Crest in Brain Development and Developmental Encephalopathies. Int. J. Mol. Sci.2023, 24, 9844.
Bruet, E.; Amarante-Silva, D.; Gorojankina, T.; Creuzet, S. The Emerging Roles of the Cephalic Neural Crest in Brain Development and Developmental Encephalopathies. Int. J. Mol. Sci. 2023, 24, 9844.
Bruet, E.; Amarante-Silva, D.; Gorojankina, T.; Creuzet, S. The Emerging Roles of the Cephalic Neural Crest in Brain Development and Developmental Encephalopathies. Int. J. Mol. Sci.2023, 24, 9844.
Bruet, E.; Amarante-Silva, D.; Gorojankina, T.; Creuzet, S. The Emerging Roles of the Cephalic Neural Crest in Brain Development and Developmental Encephalopathies. Int. J. Mol. Sci. 2023, 24, 9844.
Abstract
The neural crest, a unique cell population originating from the primitive neural field, has a multi-systemic and structural contribution to vertebrate development. At the cephalic level, the neural crest generates most of the skeletal tissues encasing the developing forebrain and provides the prosencephalon with functional vasculature and meninges. Over the last decade, we have demonstrated that the cephalic neural crest (CNC) exerts an autonomous and prominent control on forebrain and sense organs development. The present paper reviews the primary mechanisms by which CNC can orchestrate vertebrate encephalization. Demonstrating the role of the CNC as an exogenous source of patterning for the forebrain provides a novel conceptual framework with profound implications for understanding neurodevelopment. From a biomedical standpoint, these data suggest that the spectrum of neurocristopathies is broader than expected and that some neurological disorders may stem from CNC dysfunctions.
Keywords
neural crest; mesectoderm; embryology; evolution; forebrain development
Subject
Biology and Life Sciences, Anatomy and Physiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
