Version 1
: Received: 19 February 2023 / Approved: 27 February 2023 / Online: 27 February 2023 (08:42:14 CET)
How to cite:
Reed, R. The Case For Including Neuroprotective Factors in Sporadic Creutzfeldt-Jakob Questionnaires. Preprints2023, 2023020461. https://doi.org/10.20944/preprints202302.0461.v1
Reed, R. The Case For Including Neuroprotective Factors in Sporadic Creutzfeldt-Jakob Questionnaires. Preprints 2023, 2023020461. https://doi.org/10.20944/preprints202302.0461.v1
Reed, R. The Case For Including Neuroprotective Factors in Sporadic Creutzfeldt-Jakob Questionnaires. Preprints2023, 2023020461. https://doi.org/10.20944/preprints202302.0461.v1
APA Style
Reed, R. (2023). The Case For Including Neuroprotective Factors in Sporadic Creutzfeldt-Jakob Questionnaires. Preprints. https://doi.org/10.20944/preprints202302.0461.v1
Chicago/Turabian Style
Reed, R. 2023 "The Case For Including Neuroprotective Factors in Sporadic Creutzfeldt-Jakob Questionnaires" Preprints. https://doi.org/10.20944/preprints202302.0461.v1
Abstract
Background: Demonstrate a theoretical and empirical justification for including potentially protective factors in Sporadic Creutzfeldt-Jakob case-controlled studies alongside the almost exclusively studied risk-enhancing factors. Methods: Synthesize existing sCJD and Alzheimer's disease (AD) research to suggest the plausibility of shared neuroprotective factors. A fixed effects longitudinal analysis of 26 countries across 10 time periods examines whether factors identified to protect against AD are associated with population-level sCJD incidence rates. Results: Increased consumption of beans and nuts, both of which are thought to protect against AD risk, is associated with lower population level sCJD incidence. Conclusion: This study suggests that factors that protect against other neurodegenerative diseases might offer protection from sCJD. The low marginal burden of including protective factors in sCJD questionnaires offers a chance to better understand sCJD at little additional cost.
Keywords
Prion Disease; Creutzfeldt-Jakob; Diet; Dementia
Subject
Medicine and Pharmacology, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
