Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

The Similar and Distinct Roles of Satellite Glial Cells and Astrocytes in Neuropathic Pain

Version 1 : Received: 25 February 2023 / Approved: 27 February 2023 / Online: 27 February 2023 (06:35:32 CET)

A peer-reviewed article of this Preprint also exists.

McGinnis, A.; Ji, R.-R. The Similar and Distinct Roles of Satellite Glial Cells and Spinal Astrocytes in Neuropathic Pain. Cells 2023, 12, 965. McGinnis, A.; Ji, R.-R. The Similar and Distinct Roles of Satellite Glial Cells and Spinal Astrocytes in Neuropathic Pain. Cells 2023, 12, 965.

Abstract

Preclinical studies have identified glial cells as pivotal players in the genesis and maintenance of neuropathic pain after nerve injury associated with diabetes, chemotherapy, major surgeries, and virus infections. Satellite glial cells (SGCs) in the dorsal root and trigeminal ganglia of the peripheral nervous system (PNS) and astrocytes in the central nervous system (CNS) express similar molecular markers and are protective under physiological conditions. They also serve similar functions in the genesis and maintenance of neuropathic pain, downregulating some of their homeostatic functions and driving pro-inflammatory neuro-glial interactions in the PNS and CNS, i.e. “gliopathy”. However, the role of SGCs in neuropathic pain is not simply as “peripheral astrocytes”. We delineate how these peripheral and central glia participate in neuropathic pain by producing different mediators, engaging different parts of neurons, and becoming active at different stages following nerve injury. Finally, we highlight the recent findings that SGCs are enriched with proteins related to fatty acid metabolism and signaling such as Apo-E, FABP7, and LPAR1. Targeting SGCs and astrocytes may lead to novel therapeutics for the treatment of neuropathic pain.

Keywords

dorsal root ganglia; fatty acids; gliopathy; nerve injury; spinal cord

Subject

Biology and Life Sciences, Cell and Developmental Biology

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