Review
Version 1
Preserved in Portico This version is not peer-reviewed
The Role of a Lung Vascular Endothelium Enriched Gene TMEM100
Version 1
: Received: 18 February 2023 / Approved: 20 February 2023 / Online: 20 February 2023 (09:39:09 CET)
A peer-reviewed article of this Preprint also exists.
Pan, J.; Liu, B.; Dai, Z. The Role of a Lung Vascular Endothelium Enriched Gene TMEM100. Biomedicines 2023, 11, 937. Pan, J.; Liu, B.; Dai, Z. The Role of a Lung Vascular Endothelium Enriched Gene TMEM100. Biomedicines 2023, 11, 937.
Abstract
Transmembrane protein 100 (TMEM100) plays an important role in angiogenesis, vascular morphogenesis, integrity and cardiovascular development. TMEM100 is a downstream target of the BMP9/10 and BMPR2/ALK1 signaling pathways. Our recent study demonstrates TMEM100 is a lung endothelium enriched gene. Endothelial-specific deletion of Tmem100 impairs lung endothelial cells regeneration. Activation of Tmem100 signaling represents a novel strategy for lung vascular repair and regeneration. It is interesting and important to understand the roles of TMEM100 in the physiological and pathological conditions. In this review, we summarized the current knowledge of TMEM100.
Keywords
Pulmonary vasculature; BMP signaling; angiogenesis; vascular biology; lung
Subject
Biology and Life Sciences, Anatomy and Physiology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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