Clinical Utility of the FilmArray® Blood Culture Identification (BCID) Panel for the Diagnosis of Neonatal Sepsis

María Caunedo-Jiménez; Belén Fernández-Colomer; Jonathan Fernández-Suárez; Rosa Patricia Arias-Llorente; Sonia Lareu-Vidal; Laura Mantecón-Fernandez; Gonzalo Solís-Sánchez; Marta Suárez-Rodríguez

doi:10.20944/preprints202302.0014.v1

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preprints.org > biology and life sciences > immunology and microbiology > doi: 10.20944/preprints202302.0014.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Clinical Utility of the FilmArray® Blood Culture Identification (BCID) Panel for the Diagnosis of Neonatal Sepsis

María Caunedo-Jiménez

Belén Fernández-Colomer

^* ,

Jonathan Fernández-Suárez

Rosa Patricia Arias-Llorente

Sonia Lareu-Vidal

Laura Mantecón-Fernandez

Gonzalo Solís-Sánchez

Marta Suárez-Rodríguez

Version 1 : Received: 30 January 2023 / Approved: 1 February 2023 / Online: 1 February 2023 (11:50:19 CET)

A peer-reviewed article of this Preprint also exists.

Caunedo-Jiménez, M.; Fernández-Colomer, B.; Fernández-Suárez, J.; Arias-Llorente, R.P.; Lareu-Vidal, S.; Mantecón-Fernández, L.; Solís-Sánchez, G.; Suárez-Rodríguez, M. Clinical Utility of the FilmArray^® Blood Culture Identification (BCID) Panel for the Diagnosis of Neonatal Sepsis. Microorganisms 2023, 11, 732. Caunedo-Jiménez, M.; Fernández-Colomer, B.; Fernández-Suárez, J.; Arias-Llorente, R.P.; Lareu-Vidal, S.; Mantecón-Fernández, L.; Solís-Sánchez, G.; Suárez-Rodríguez, M. Clinical Utility of the FilmArray® Blood Culture Identification (BCID) Panel for the Diagnosis of Neonatal Sepsis. Microorganisms 2023, 11, 732.

Abstract

This prospective single-center study was designed to assess the clinical utility of the FilmArray® blood culture identification (BCID) panel for improving the diagnostic accuracy in neonatal sepsis. Results obtained using the FilmArray® BCID panel were correlated with results of blood culture in all consecutive neonates with suspicion of early-onset (EOS) and late-onset sepsis (LOS) attended in our service over a 2-year period. A total of 102 blood cultures from 92 neonates were included, 69 (67.5%) in cases of EOS and 33 (32.3%) in LOS. The FilmArray® BCID panel was performed in negative culture bottles at a median of 10 hours of blood culture incubation (range 7.5-20 hours), without differences by the type of sepsis. The FilmArray® BCID panel showed a 66.7% sensitivity, 100% specificity, 100% positive predictive value, and 95.7% negative predictive value. There were four false-negative cases, three of which of Streptococcus epidermidis in neonates with LOS and one case of Granulicatella adiacens in one neonate with EOS. We conclude that the use of the FilmArray® BCID panel in negative blood cultures from neonates with clinical suspicion of sepsis is useful in decision-making of starting or early withdrawal of empirical antimicrobials because of the high specificity and negative predictive values of this assay.

Keywords

neonatal sepsis; blood culture; early-onset sepsis; late-onset sepsis; FilmArray® blood culture identification panel; neonates.

Subject

Biology and Life Sciences, Immunology and Microbiology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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