Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

‘Langya’ Virus, A Zoonotic Henipavirus Recently Emerged in China, Public Health Concerns, and Counteracting Prevention and Control Measures- An Update

Version 1 : Received: 27 January 2023 / Approved: 28 January 2023 / Online: 28 January 2023 (04:53:17 CET)

How to cite: Sah, R.; Shah, J.; Rao, P.; Padhi, B.K.; Mohanty, A.; Yatoo, M.I.; Chandran, D.; El Sh, N.A.; SV, P.; Emran, T.B.; Chakraborty, C.; Dhama, K. ‘Langya’ Virus, A Zoonotic Henipavirus Recently Emerged in China, Public Health Concerns, and Counteracting Prevention and Control Measures- An Update. Preprints 2023, 2023010518. https://doi.org/10.20944/preprints202301.0518.v1 Sah, R.; Shah, J.; Rao, P.; Padhi, B.K.; Mohanty, A.; Yatoo, M.I.; Chandran, D.; El Sh, N.A.; SV, P.; Emran, T.B.; Chakraborty, C.; Dhama, K. ‘Langya’ Virus, A Zoonotic Henipavirus Recently Emerged in China, Public Health Concerns, and Counteracting Prevention and Control Measures- An Update. Preprints 2023, 2023010518. https://doi.org/10.20944/preprints202301.0518.v1

Abstract

The risk of 'zoonotic spillovers,' or the transmission of viruses from animals to humans, has been raised by climate change and the devastation of nature, as infectious disease experts have long warned. Even as the world works to stop the spread of the currently unfolding pandemic of coronavirus disease 2019 (COVID-19) and the breakout of monkeypox virus (MPXV), a new animal virus, the Langya henipavirus (LayV), has been discovered in humans in Eastern China. The scientists say there is little danger of the virus spreading among humans, but it shares genetic material with Hendra virus and Nipah virus, two other henipaviruses that infect humans and cause life-threatening respiratory diseases. Humans infected with LayV can expect to experience high body temperature, cough, weariness, poor appetite, muscle discomfort, myalgia, nausea and vomiting. It is likely that the virus will spread from animals to humans. Currently, the health authorities of Taiwan and other health organizations are tracking the progress of the ailment to ensure it does not reach humans. Researchers have examined 25 species of small wild animals for presence of the virus, and so far, shrews are the only ones that have tested positive for the virus's RNA. Based on these results, shrews are a possible candidate for the virus's natural reservoir. Too far, no therapies or vaccines have been developed and licensed for henipaviruses like the LayV. When other therapies fail to alleviate viral infections, ribavirin may be the next best thing. The need for novel vaccinations against the LayV infection and the timely delivery of these vaccines to areas at high epidemiological risk is real. To lessen the likelihood of a health calamity being caused by this newly developing virus, it is crucial to conduct active surveillance in a transparent and globally collaborative manner. The questions that have not been answered yet require additional study.

Keywords

Langya virus; henipavirus; animal spillover; zoonosis; public health concerns; prevention and control measures

Subject

Biology and Life Sciences, Virology

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