Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Dyslipidemia in Adults with Type 2 Diabetes in a Rural Community in Ganadougou, Mali: A Cross-Sectional Study

Version 1 : Received: 21 January 2023 / Approved: 28 January 2023 / Online: 28 January 2023 (01:29:07 CET)

How to cite: Diawara, A.; Coulibaly, D.M.; Kone, D.; Traore, M.A.; Bazi, D.S.; Kassogue, O.; Sylla, D.; Fofana, F.G.; Diabaté, O.; Sangaré, M.; Nieantao, I.A.; Keїta, K.; Diarra, M.; Li, J.; Cisse, C.; Abbas, T.Y.; Zheng, C.; Fatumo, S.; Traore, K.; Wele, M.; Diakité, M.; Doumbia, S.O.; Shaffer, J.G. Dyslipidemia in Adults with Type 2 Diabetes in a Rural Community in Ganadougou, Mali: A Cross-Sectional Study. Preprints 2023, 2023010508. https://doi.org/10.20944/preprints202301.0508.v1 Diawara, A.; Coulibaly, D.M.; Kone, D.; Traore, M.A.; Bazi, D.S.; Kassogue, O.; Sylla, D.; Fofana, F.G.; Diabaté, O.; Sangaré, M.; Nieantao, I.A.; Keїta, K.; Diarra, M.; Li, J.; Cisse, C.; Abbas, T.Y.; Zheng, C.; Fatumo, S.; Traore, K.; Wele, M.; Diakité, M.; Doumbia, S.O.; Shaffer, J.G. Dyslipidemia in Adults with Type 2 Diabetes in a Rural Community in Ganadougou, Mali: A Cross-Sectional Study. Preprints 2023, 2023010508. https://doi.org/10.20944/preprints202301.0508.v1

Abstract

Dyslipidemia is a disorder where abnormally lipid concentrations circulate in the bloodstream. The disorder is common in type 2 diabetics (T2D) and is linked with T2D comorbidities, particularly cardiovascular disease. Dyslipidemia in T2D is typically characterized by elevated plasma triglyceride and low high-density lipoprotein cholesterol (HDL-C) levels. There is a significant gap in the literature regarding dyslipidemia in rural parts of Africa, where lipid profiles may not be routinely captured through standard surveillance activities. This study aimed to characterize the prevalence and demographic profile of dyslipidemia in T2D patients in the rural community of Ganadougou, Mali. We performed a cross-sectional study of 104 subjects with T2D in Ganadougou between November 2021 and March 2022. Demographic and lipid profiles were collected through cross-sectional surveys and blood tests. The overall prevalence of dyslipidemia in T2D patients was 87.5% (91/104), which did not differ by sex (p = .368). High low-density lipoprotein cholesterol (LDL-C) was the most common lipid abnormality (78.9%, [82/104]). Dyslipidemia was associated with age and hypertension status (p = .013 and p = .036, respectively). High total and high LDL-C parameters were significantly associated with hypertension (p = .029 and p = .006, respectively). In low-resource settings such as rural Mali, there is a critical need to improve infrastructure for routine dyslipidemia screening to guide its prevention and intervention approaches. The high rates of dyslipidemia observed in Gandadougou, consistent with concomitant increases in cardiovascular diseases in Africa suggest that lipid profile assessments should be incorporated into routine medical care for T2D patients in African rural settings.

Keywords

cholesterol; cross-sectional study; dyslipidemia; lipids; Mali; type 2 diabetes

Subject

Medicine and Pharmacology, Endocrinology and Metabolism

Comments (1)

Comment 1
Received: 5 February 2023
Commenter: (Click to see Publons profile: )
The commenter has declared there is no conflict of interests.
Comment: Interesting article with an informative title, addressing an important contemporary issue. The article is well organized and splendidly written. It would be a valuable addition to the existing body of knowledge.

Just a few remarks towards improving the manuscript:

(1) Abstract:
Sentence ‘Demographic and lipid profiles were collected through cross-sectional surveys and blood tests': better to separate these two factors ('Demographic characteristics’ and ‘lipid profiles’) putting each with its own collection method.

(2)Methodology section:
a) Authors may wish to start this section with a clear succinct up-front statement of their research method(s) (e. g “This is a prospective observational cross-section study carried out between November 2021 and March 2022, aiming at ....").
b) Figure 1 caprion: Better to remove 'The star represents Mali’s capital city of Bamako’ because it is repeated later in the same caption.
c) The part in the Figure 1 caption: 'Participating municipalities included Nièna, Zanièna,Benkadi, and Finkolo-Ganadougou. Ganadougou is approximately 323 kilometers (201 miles) southeast of Bamako’ may better be moved to the main text with referencing or disclosing the source of all the demographic and geographical information.
d) Equation of the sample size can be put in a separate line (or block text) in a central alignment, with the explanations of its symbols in the next line(s).
e) Definitions: Suggest putting each defined criterion or diagnosis in a subheading or paragraph.

(3) Results:
Omit ‘age group’ in the sentence: ‘Dyslipidemia status did not statistically differ according to sex, age group, T2D treatment, T2D duration, hypercreatinemia status, glycemic balance, or physical activity.’ (as age group showed statistical significance).

(4) Discussion:
a) The sentence ‘For this reason, telehealth and education campaigns may provide viable solutions.’: Kindly elaborate more on telehealth role, and place as short sentence also in the conclusion as one of the recommendations.

b) Regarding the statement ‘For instance, it is estimated that 59.7% of T2D cases are undiagnosed’: please explain what specific base population is resembled by ‘59.7%’; and remember to reference the statement.

(5) Conclusions:
The study elicited important info and situation discoveries that would greatly guide public health. Specific clear recommendations to health authorities or concerned chronic disease prevention program entities should be provided/suggested here.
Thank you
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