Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Effects of Molecular Hydrogen in the Pathophysiology and Management of Cardiovascular and Metabolic Diseases

Ram B Singh
ORCID logo ,
Ghizal Fatima
ORCID logo ,
Jan Fedacko
,
Villiam Mojto
* ,
Zuzana Sumbalová
ORCID logo ,
Alex Tarnava
ORCID logo ,
Oleg Pokotilo
ORCID logo ,
Eugeny I Nazarov
,
Kyu-Jae Lee
,
Kristina. Ferenczyova
,
Jana Vlkovlkova
,
Barbora Kalocayova
ORCID logo ,
Barbora Kalocayova
,
Jan Slezak
ORCID logo ,
Cheol-Su Kim
ORCID logo
Version 1 : Received: 2 January 2023 / Approved: 26 January 2023 / Online: 26 January 2023 (08:20:52 CET)

A peer-reviewed article of this Preprint also exists.

Singh, R.B.; Sumbalova, Z.; Fatima, G.; Mojto, V.; Fedacko, J.; Tarnava, A.; Pokotylo, O.; Gvozdjakova, A.; Ferenczyova, K.; Vlkovicova, J.; et al. Effects of Molecular Hydrogen in the Pathophysiology and Management of Cardiovascular and Metabolic Diseases. Reviews in Cardiovascular Medicine 2024, 25, 33, doi:10.31083/j.rcm2501033. Singh, R.B.; Sumbalova, Z.; Fatima, G.; Mojto, V.; Fedacko, J.; Tarnava, A.; Pokotylo, O.; Gvozdjakova, A.; Ferenczyova, K.; Vlkovicova, J.; et al. Effects of Molecular Hydrogen in the Pathophysiology and Management of Cardiovascular and Metabolic Diseases. Reviews in Cardiovascular Medicine 2024, 25, 33, doi:10.31083/j.rcm2501033.

Abstract

There is evidence that behavioral risk factors such as western type diet, and life style can predispose to oxidative stress, deficiency in antioxidant status, hyperglycemia, dyslipidemia and increase in inflammation in tissues of various organs: beta cells of the pancreas, LDL receptors in the hepatocytes, endothelium, neurons, osteocytes and gut. Further studies indicate that diets rich in antioxidant flavonoids, omega-3 fatty acids and fiber in foods were inversely associated whereas western-type foods were positively associated with risk of mortality due to cardiovascular diseases (CVDs). One important cause for beneficial effects of diet may be certain foods and nutrients such as vegetables, fruits and whole grains that are rich in fiber and flavonoids, known to produce liters og molecular hydrogen in the gut. It seems that, high-fiber diets, prebiotic and probiotics can produce greater hydrogen, which acts as an antioxidant and may inhibit free radical generation. Recent studies indicate that molecular hydrogen can inhibit hydroxyl and nitrosyl radicals and can directly act as antioxidant in the cells and tissues, which can cause marked decline in oxidative stress and inflammation leading to significant decline in CVDs and metabolic diseases. Clinical and experimental studies indicate that hydrogen therapy such as hydrogen rich water can provide benefits in the management of CVDs and metabolic diseases. Larger studies are necessary to verify the role of hydrogen administration in CVDs.

Keywords

Antioxidant; free radical stress; endothelial dysfunction; dyslipidemia; diet

Subject

Medicine and Pharmacology, Dietetics and Nutrition

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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