Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

A Comparative Analysis of Human Hepatic Lesions in Dengue, Yellow Fever, and Chikungunya: Revisiting Histopathological Changes in the Light of Modern Knowledge of Cell Pathology

Yasmin Ribeiro
,
Luiz Fábio Magno Falcão
ORCID logo ,
Vanessa Cavaleiro Smith
,
Jorge Rodrigues Sousa
,
Carla Pagliari
ORCID logo ,
Edna Cristina dos Santos Franco
,
Ana Cecília Ribeiro Cruz
ORCID logo ,
Jannifer O. Chiang
ORCID logo ,
Lívia Caricio Martins
ORCID logo ,
Juliana Abreu Lima Nunes
,
Felipe Souza da Silva Vilacoert
,
Lais Carneiro dos Santos
,
Matheus Perini Furlaneto
,
Hellen Thaís Fuzii
,
Marcos Virgilio Bertonsin Filho
,
Luccas Delgado Da Costa
,
Maria Irma Seixas Duarte
ORCID logo ,
Ismari Perini Furlaneto
ORCID logo ,
Arnaldo Jorge Martins-Filho
ORCID logo ,
Tinara Aarão
,
Pedro F.C. Vasconcelos
ORCID logo ,
Juarez Antônio Simões Quaresma
* ORCID logo
Version 1 : Received: 14 January 2023 / Approved: 16 January 2023 / Online: 16 January 2023 (02:55:43 CET)

A peer-reviewed article of this Preprint also exists.

Ribeiro, Y.P.; Falcão, L.F.M.; Smith, V.C.; de Sousa, J.R.; Pagliari, C.; Franco, E.C.S.; Cruz, A.C.R.; Chiang, J.O.; Martins, L.C.; Nunes, J.A.L.; Vilacoert, F.S.S.; Santos, L.C.; Furlaneto, M.P.; Fuzii, H.T.; Bertonsin Filho, M.V.; da Costa, L.D.; Duarte, M.I.S.; Furlaneto, I.P.; Martins Filho, A.J.; Aarão, T.L.S.; Vasconcelos, P.F.C.; Quaresma, J.A.S. Comparative Analysis of Human Hepatic Lesions in Dengue, Yellow Fever and Chikungunya: Revisiting Histopathological Changes in the Light of Modern Knowledge of Cell Pathology. Pathogens 2023, 12, 680. Ribeiro, Y.P.; Falcão, L.F.M.; Smith, V.C.; de Sousa, J.R.; Pagliari, C.; Franco, E.C.S.; Cruz, A.C.R.; Chiang, J.O.; Martins, L.C.; Nunes, J.A.L.; Vilacoert, F.S.S.; Santos, L.C.; Furlaneto, M.P.; Fuzii, H.T.; Bertonsin Filho, M.V.; da Costa, L.D.; Duarte, M.I.S.; Furlaneto, I.P.; Martins Filho, A.J.; Aarão, T.L.S.; Vasconcelos, P.F.C.; Quaresma, J.A.S. Comparative Analysis of Human Hepatic Lesions in Dengue, Yellow Fever and Chikungunya: Revisiting Histopathological Changes in the Light of Modern Knowledge of Cell Pathology. Pathogens 2023, 12, 680.

Abstract

Arboviruses such as yellow fever virus (YFV), dengue virus (DENV), and chikungunya virus (CHIKV) presenting wide global dissemination and the pathogenic profile developed in infected individuals, which develop from nonspecific clinical conditions to severe forms, characterized by the promotion of significant lesions in different organs of the harborer, culminating in multiple organ dysfunction. To characterize, quantify, and compare the patterns of histopathological alterations in human liver samples from patients with yellow fever (YF), dengue fever (DF), and chikungunya fever (CF). Analytical cross-sectional study by histopathological analysis with 70 samples of liver patients, collected from 2000 to 2017, with confirmed laboratory diagnosis who died due to infection and complications by the YF, DF, and CF. Of the histopathological findings in human liver samples there was a significant difference between the control and infection groups, with a predominance of alterations in the midzonal area of the three cases analyzed, among the arboviruses studied, the hepatic involvement in cases of YF showed greater intensity of histopathological changes. Among the alterations evaluated, cell swelling, microvesicular steatosis and apoptosis were classified as degree of tissue damage from severe to very severe. The pathological abnormalities associated with infection by YFV, DENV, and CHIKV showed predominance of changes in the midzonal area. We also noted that in among of the arboviruses studied, liver involvement in cases of YFV infection was more intense.

Keywords

Arboviruses; Histopathology; Cell death; Necrosis; Steatosis; Liver

Subject

Biology and Life Sciences, Virology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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