Gupta, M.N.; Uversky, V.N. Pre-Molten, Wet, and Dry Molten Globules en Route to the Functional State of Proteins. Int. J. Mol. Sci.2023, 24, 2424.
Gupta, M.N.; Uversky, V.N. Pre-Molten, Wet, and Dry Molten Globules en Route to the Functional State of Proteins. Int. J. Mol. Sci. 2023, 24, 2424.
Gupta, M.N.; Uversky, V.N. Pre-Molten, Wet, and Dry Molten Globules en Route to the Functional State of Proteins. Int. J. Mol. Sci.2023, 24, 2424.
Gupta, M.N.; Uversky, V.N. Pre-Molten, Wet, and Dry Molten Globules en Route to the Functional State of Proteins. Int. J. Mol. Sci. 2023, 24, 2424.
Abstract
Transition between the unfolded and native states of the ordered globular proteins is accompanied by accumulation of several intermediates, such as pre-molten globule, wet molten globule, and dry molten globule. Structurally equivalent conformations can serve as native functional states of intrinsically disordered proteins. This overview captures the characteristics and importance of these molten globules in both structured and intrinsically disordered proteins. It also discusses examples of engineered molten globules. The formation of these intermediates under the conditions of macromolecular crowding and their interactions with nanomaterials are also reviewed.
Keywords
Baroenzymology; Cryoenzymology; Intrinsic disorder; Intrinsically disordered proteins; Macromolecular crowding; Nanomaterials; Partially folded intermediate; Protein denaturation; Protein engineering; Protein flexibility; Protein folding; Protein function; Protein stability; Protein structure; Protein refolding; Protein unfolding
Subject
Biology and Life Sciences, Biophysics
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
