Benito, L.A.O.; Kogawa, E.M.; Silva, C.M.S.; Melo, F.F.; Sales-Peres, S.H.C.; Silva, I.C.R.; Karnikowski, M.G.O. Bariatric Surgery and Vitamin D: Trends in Older Women and Association with Clinical Features and VDR Gene Polymorphisms. Nutrients2023, 15, 799.
Benito, L.A.O.; Kogawa, E.M.; Silva, C.M.S.; Melo, F.F.; Sales-Peres, S.H.C.; Silva, I.C.R.; Karnikowski, M.G.O. Bariatric Surgery and Vitamin D: Trends in Older Women and Association with Clinical Features and VDR Gene Polymorphisms. Nutrients 2023, 15, 799.
Benito, L.A.O.; Kogawa, E.M.; Silva, C.M.S.; Melo, F.F.; Sales-Peres, S.H.C.; Silva, I.C.R.; Karnikowski, M.G.O. Bariatric Surgery and Vitamin D: Trends in Older Women and Association with Clinical Features and VDR Gene Polymorphisms. Nutrients2023, 15, 799.
Benito, L.A.O.; Kogawa, E.M.; Silva, C.M.S.; Melo, F.F.; Sales-Peres, S.H.C.; Silva, I.C.R.; Karnikowski, M.G.O. Bariatric Surgery and Vitamin D: Trends in Older Women and Association with Clinical Features and VDR Gene Polymorphisms. Nutrients 2023, 15, 799.
Abstract
(1) Background: Obesity and its comorbidities can cause burdens and limitations. Bariatric surgery (BS) is indicated as a safe procedure to reduce body mass and improve present comorbidities. Yet, several complications were reported, like vitamin D [25(OH)D] deficiency. We evaluated if 25(OH)D serum levels relate to clinical characteristics, symptoms, or habits in women after their BS and whether the vitamin D receptor (VDR) gene's TaqI and FokI polymorphisms affected 25(OH)D levels and the total body bone mineral density (TBBMD). (2) Methods: This cohort cross-sectional comparative analytical prospective study consisted of 27 women, 61.6 ± 5.0 years, submitted to BS one year prior at a public reference hospital, DF-Brazil. All participants were asked to follow the physical and dietary activity recommendations and received vitamin D3 supplements. Their anthropometric, biochemical, and immunological measurements and blood samples were obtained. (3) Results: 73.3% of participants had low 25(OH)D levels, and their levels correlated positively with TBBMD and negatively with systolic pressure. VDR TaqI did not affect 25(OH)D levels, whereas VDR FokI's allele f presence correlated to a median rise in 25(OH)D levels. Neither polymorphism correlated to TBBMD. (4) Conclusions: 25(OH)D levels were positively correlated with TBBMD, negatively with systolic blood pressure, and were higher in those with the VDR FokI allele f.
Biology and Life Sciences, Biochemistry and Molecular Biology
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