Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Isolation and Bioassay of a New Terminalone A from Terminalia arjuna

Bushra Bushra
,
Khalil ur Rehman
* ,
Dilfaraz Khan
,
Abdulrahman A. Almehizia
ORCID logo ,
Ahmed M. Naglah
,
Asma S. Al-Wasidi
,
Moamen S. Refat
,
Mohamed Y. El-Sayed
,
Hamid Ullah
,
Shafiullah Khan
*
Version 1 : Received: 21 December 2022 / Approved: 26 December 2022 / Online: 26 December 2022 (11:02:19 CET)

A peer-reviewed article of this Preprint also exists.

Bushra; Rehman, K.U.; Khan, D.; Almehizia, A.A.; Naglah, A.M.; Al-Wasidi, A.S.; Refat, M.S.; El-Sayed, M.Y.; Ullah, H.; Khan, S. Isolation and Bioassay of a New Terminalone A from Terminalia arjuna. Molecules 2023, 28, 1015. Bushra; Rehman, K.U.; Khan, D.; Almehizia, A.A.; Naglah, A.M.; Al-Wasidi, A.S.; Refat, M.S.; El-Sayed, M.Y.; Ullah, H.; Khan, S. Isolation and Bioassay of a New Terminalone A from Terminalia arjuna. Molecules 2023, 28, 1015.

Abstract

Terminalia arjuna possesses significant cardio protective, antidiabetic and antioxidant properties as these properties are described in Ayurveda. In the present study, three flavonoids were isolated through the separation and chromatographic purification of the whole plant material of T. arjuna. Spectroscopic characterization identified one of them as a new flavonoid “Terminalone A (1)” and two known flavonoids i.e. 6-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4H-chromen-4-one (2) and 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one (3). The bioactivity studies showed considerable antibacterial and antioxidant (DPPH was used as a scavenger) potential for all the three compounds 1-3 where the compound 1 showed strong antibacterial and antioxidant activity.

Keywords

Terminalia arjuna; Terminalone A; flavonoids; antibacterial; antioxidants; reactive oxygen specie

Subject

Chemistry and Materials Science, Organic Chemistry

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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