Article
Version 1
Preserved in Portico This version is not peer-reviewed
Microchimerism, PERV and xenotransplantation
Version 1
: Received: 6 December 2022 / Approved: 13 December 2022 / Online: 13 December 2022 (01:59:16 CET)
A peer-reviewed article of this Preprint also exists.
Denner, J. Microchimerism, PERV and Xenotransplantation. Viruses 2023, 15, 190. Denner, J. Microchimerism, PERV and Xenotransplantation. Viruses 2023, 15, 190.
Abstract
Microchimerism is the presence of cells in an individual that have originated from another individual. The most common form of microchimerism is fetomaternal microchimerism, i.e., cells from a fetus pass through the placenta and establish cell lineages within the mother. Microchimerism was also described after transplantation of human organs in human recipients. Consequently, microchimerism may also be expected in xenotransplantation using pig cells or organs. Indeed, microchimerism was described in patients after xenotransplantations as well as in non-human primates after transplantation of pig organs. Here for the first time a comprehensive review of microchimerism in xenotransplantation is given. Since pig cells contain porcine endogenous retroviruses (PERVs) in their genome, detection of proviral DNA in the transplant recipients may be misinterpreted as infection of the recipient with PERV. To prevent this, methods discriminating between infection and microchimerism are described. This knowledge will be important for the interpretation of screening results in forthcoming human xenotransplantations.
Keywords
xenotransplanation; microchimerism; porcine endogenous retroviruses; detection methods
Subject
Biology and Life Sciences, Virology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Comments (0)
We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.
Leave a public commentSend a private comment to the author(s)
* All users must log in before leaving a comment
