Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Waves, Protein Synthesis and Resonance in the Brain: a New Approach for a Long Term Memory

Version 1 : Received: 6 December 2022 / Approved: 12 December 2022 / Online: 12 December 2022 (12:11:00 CET)

How to cite: Muresan, L.; Jalba, A. Waves, Protein Synthesis and Resonance in the Brain: a New Approach for a Long Term Memory. Preprints 2022, 2022120201. https://doi.org/10.20944/preprints202212.0201.v1 Muresan, L.; Jalba, A. Waves, Protein Synthesis and Resonance in the Brain: a New Approach for a Long Term Memory. Preprints 2022, 2022120201. https://doi.org/10.20944/preprints202212.0201.v1

Abstract

Conclusive evidence that speci c long-term memory formation relies on den- dritic growth and structural synaptic changes has proven elusive. Connec- tionist models of memory based on this hypothesis are confronted with the so-called plasticity stability dilemma or catastrophic interference. Other fun- damental limitations of these models are the feature binding problem, the speed of learning, the capacity of the memory, the localisation in time of an event and the problem of spatio-temporal pattern generation. This paper suggests that the generalisation and long-term memory mechanisms are not correlated. Only the development and the improvement of the feature ex- tractors in the cortex involves structural synaptic changes. We suggest the long-term memory has a separate mechanism which involves protein synthe- sis to encode the information into the structure of these proteins. A model of memory should be capable of explaining the di erence between memorisation and learning. Learning has in our approach two di erent mechanisms. The generalisation in the brain is handled by the proper development of the links between neurons via synapses. The Hebbian learning rule could be applied only for this part of learning. Storing an internal ring pattern involves, in our approach, a new mechanism which puts the information regarding this ring pattern into the structure of special proteins in such a way that it can be retrieved later. The hypotheses introduced in this article includes a physiological assumption which has not been yet verifi ed because it is not currently experimentally accessible. Keywords: Waves, Protein Synthesis, Resonance, Long Term Memory Preprint submitted to Neural Networks

Keywords

Waves; Protein Synthesis; Resonance; Long Term Memory

Subject

Biology and Life Sciences, Biophysics

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