Standard Gibbs Energy of Binding of the gp120 Antigen of HIV-1 to the CD4 Receptor

Marko Popovic

doi:10.20944/preprints202211.0482.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 23 November 2022 / Approved: 25 November 2022 / Online: 25 November 2022 (12:44:38 CET)

HIV-1, like other viruses, represents an open thermodynamic system. This is why it is important to know its thermodynamic properties. Virus-host interactions are performed at the membrane as antigen-receptor binding. Antigen-receptor binding represents a chemical reaction, similar to protein-ligand interactions. The driving force for antigen-receptor binding is Gibbs energy of binding. Knowing Gibbs energy of binding, it is possible to estimate the rate of virus binding and entry into host cells. In this paper, binding equilibrium constants and standard Gibbs energies of binding between the HIV-1 gp120 antigen and the CD4 receptor have been reported at 4°C, 22°C and 37°C.

Biothermodynamics of viruses; HIV-1; Binding constant; Gibbs energy of binding; Antigen-receptor binding

Biology and Life Sciences, Virology

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Standard Gibbs Energy of Binding of the gp120 Antigen of HIV-1 to the CD4 Receptor

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