Modulated Electro-Hyperthermia Enhances Tumor Cell Sus-ceptibility to Gamma Delta T Cell-Mediated Cytotoxicity and Tumor Infiltration

Yi-Ching Chen; Yu-Kang Chang; Min-Che Tung; Keng-Li Lan; Yuk-Wah Tsang; Heng-Jui Chang; Gin-Hao Hu; Long-Sheng Lu; Stephen W Leung; Pei-Wei Shueng; Shih-Kai Hung; Yee Chao; Yu-Shan Wang; Yu-Chi Chiu

doi:10.20944/preprints202211.0466.v1

Submit preprint
How it Works
Instructions for Authors
Subject Areas
Advisory Board
screening preprints
About
Awards
Log in/Register

Instructions for Authors
Awards
About
FAQ
Submit Log in/Register

Share this article with

Create alert

Email:

Load new image

preprints.org > medicine and pharmacology > oncology and oncogenics > doi: 10.20944/preprints202211.0466.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Modulated Electro-Hyperthermia Enhances Tumor Cell Sus-ceptibility to Gamma Delta T Cell-Mediated Cytotoxicity and Tumor Infiltration

^* ,

Version 1 : Received: 24 November 2022 / Approved: 25 November 2022 / Online: 25 November 2022 (03:15:21 CET)

How to cite: Chen, Y.; Chang, Y.; Tung, M.; Lan, K.; Tsang, Y.; Chang, H.; Hu, G.; Lu, L.; Leung, S.W.; Shueng, P.; Hung, S.; Chao, Y.; Wang, Y.; Chiu, Y. Modulated Electro-Hyperthermia Enhances Tumor Cell Sus-ceptibility to Gamma Delta T Cell-Mediated Cytotoxicity and Tumor Infiltration. Preprints 2022, 2022110466. https://doi.org/10.20944/preprints202211.0466.v1 Chen, Y.; Chang, Y.; Tung, M.; Lan, K.; Tsang, Y.; Chang, H.; Hu, G.; Lu, L.; Leung, S.W.; Shueng, P.; Hung, S.; Chao, Y.; Wang, Y.; Chiu, Y. Modulated Electro-Hyperthermia Enhances Tumor Cell Sus-ceptibility to Gamma Delta T Cell-Mediated Cytotoxicity and Tumor Infiltration. Preprints 2022, 2022110466. https://doi.org/10.20944/preprints202211.0466.v1

Cite

Export citation file: Bib TeX | RIS

MDPI and ACS Style

Chen, Y.; Chang, Y.; Tung, M.; Lan, K.; Tsang, Y.; Chang, H.; Hu, G.; Lu, L.; Leung, S.W.; Shueng, P.; Hung, S.; Chao, Y.; Wang, Y.; Chiu, Y. Modulated Electro-Hyperthermia Enhances Tumor Cell Sus-ceptibility to Gamma Delta T Cell-Mediated Cytotoxicity and Tumor Infiltration. Preprints 2022, 2022110466. https://doi.org/10.20944/preprints202211.0466.v1

APA Style

Chen, Y., Chang, Y., Tung, M., Lan, K., Tsang, Y., Chang, H., Hu, G., Lu, L., Leung, S.W., Shueng, P., Hung, S., Chao, Y., Wang, Y., & Chiu, Y. (2022). Modulated Electro-Hyperthermia Enhances Tumor Cell Sus-ceptibility to Gamma Delta T Cell-Mediated Cytotoxicity and Tumor Infiltration. Preprints. https://doi.org/10.20944/preprints202211.0466.v1

Chicago/Turabian Style

Chen, Y., Yu-Shan Wang and Yu-Chi Chiu. 2022 "Modulated Electro-Hyperthermia Enhances Tumor Cell Sus-ceptibility to Gamma Delta T Cell-Mediated Cytotoxicity and Tumor Infiltration" Preprints. https://doi.org/10.20944/preprints202211.0466.v1

Abstract

γδT have functions of innate and adaptive immunity, with the potential to induce durable responses while being well-tolerated, with limited adverse effects, making it attractive as a tool for immunotherapy. γδT faces challenges as a frontline tool in clinical oncology, with limited response rates due to difficulties in reaching tumor sites with consistent cytotoxic activity and strength. Modulated Electro-hyperthermia (mEHT) is a loco-regional treatment, whereby energy-transmission from an electromagnetic field selectively targets the plasma membrane of tumor cells, inducing apoptosis and activating immune cells. We hypothesized that mEHT could enhance therapeutic effects by drawing γδT to tumor cells, while also rendering tumor cells to be more susceptible to cytotoxic effects. In this study, NOD/SCID mice harboring subcutaneous human HepG2 tumors were treated with intravenous injections of γδT after mEHT treatment. This method increased infiltration of γδT into the tumor site, significantly inhibiting tumor growth as compared to monotherapy with either modality. These data suggest that γδT could mediate a potent anti-tumor effect when combined with mEHT, and provide a strong rationale for combining these modalities in clinical application for cancer treatment.

Keywords

γδT, gamma delta T; tumor-infiltrating lymphocytes; TIL; cell therapy; cancer immunotherapy; hyperthermia; modulated electro-hyperthermia

Subject

Medicine and Pharmacology, Oncology and Oncogenics

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Download PDF Download Supplementary

Comments (0)

Not displayed online.

Importance: How significant is the paper to the field?

Outstanding/highlight paper

Significant contribution

Incremental contribution

No contribution

I am not qualified to judge

Soundness of evidence/arguments presented:

Conclusions well supported

Most conclusions supported (minor revision needed)

Incomplete evidence (major revision needed)

Hypothesis, unsupported conclusions, or proof-of-principle

I am not qualified to judge

Please leave your comment to this article below.

Mathematical equations can be typed in either LaTeX formats \\[ ... \\] or $$ ... $$, or MathML format <math> ... </math>. Try the LaTeX or MathML example.

Type equation:

Preview:

Copy equation into message below

Close menu

Please click a symbol to insert it into the message box below:

Please enter the link here:

Please enter a valid URL

Optionally, you can enter text that should appear as linked text:

Copy link into message below

Close menu

Please enter or paste the URL to the image here (please only use links to jpg/jpeg, png and gif images):

Please enter a valid URL

Copy image into message below

Close menu

Type author name or keywords to filter the list of references in this group (you can add a new citation under Bibliography):

No existing citations in Discussion Group

Wikify editor is a simple editor for wiki-style mark-up. It was written by MDPI for Sciforum in 2014. The rendering of the mark-up is based on Wiky.php with some tweaks. Rendering of mathematical equations is done with MathJax. Please send us a message for support or for reporting bugs.

Close menu

Please declare any conflicts of interest you may have with this paper, financial or otherwise.

I do not have a conflict of interest

I would like to declare a conflict of interest

Display my name on the website Send my name and email address to the authors

Captcha

Renew

I accept the following conditions:

Comments must follow the standards of professional discourse and should focus on the scientific content of the article. Insulting or offensive language, personal attacks and off-topic remarks will not be permitted. Comments must be written in English. Preprints reserves the right to remove comments without notice. Readers who post comments are obliged to declare any competing interests, financial or otherwise.

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)

* All users must log in before leaving a comment

what’s this?

Add a record of this review to Publons to track and showcase your reviewing expertise across the world’s journals.

Downloads 0

Comments 0

Metrics 0

Get PDF Supplementary Files Cite Share 0

Bookmark BibSonomy Mendeley Reddit Delicious

Alerts

Notify me about updates to this article or when a peer-reviewed version is published.

Preprints.org is a free preprint server subsidized by MDPI in Basel, Switzerland.

MDPI Initiatives

SciProfiles
Sciforum
Encyclopedia
MDPI Books
Scilit
Proceedings
JAMS

Important links

How it Works
Advisory Board
FAQ
Friendly Journals
Instructions for Authors
About
Statistics

Choose the area that interest you and we will send you notifications of new preprints at your preferred frequency.

Disclaimer

We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.

RSS feed for

Preprints: The Multidisciplinary Preprint Platform

Paste the URL in your RSS reader:

https://www.preprints.org/rss

If you want to subscribe our website in subject-wide, you could find the URL by choosing in the following:

https://www.preprints.org/rss

Please note that by using ScienceDirect RSS feeds, you agree to our Terms of Use and Privacy Policy.