Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Probiotic Formulations & Gastro-Intestinal Diseases: A State-of-Art Review

Version 1 : Received: 16 November 2022 / Approved: 17 November 2022 / Online: 17 November 2022 (08:53:58 CET)

How to cite: Siddiqui, A.; Haider, R.; Aaqil, S.I.; Vohra, L.I.; Qamar, K.; Fatima, N.; Adnan, A.; Parikh, V. Probiotic Formulations & Gastro-Intestinal Diseases: A State-of-Art Review. Preprints 2022, 2022110328. https://doi.org/10.20944/preprints202211.0328.v1 Siddiqui, A.; Haider, R.; Aaqil, S.I.; Vohra, L.I.; Qamar, K.; Fatima, N.; Adnan, A.; Parikh, V. Probiotic Formulations & Gastro-Intestinal Diseases: A State-of-Art Review. Preprints 2022, 2022110328. https://doi.org/10.20944/preprints202211.0328.v1

Abstract

Probiotics are namely yeast and bacteria which are regarded as dietary supplements and food. Many probiotics are being commonly used now, the most frequently used, lactic acid bacteria are called Lactobacillus and Bifidobacterium. Many of the diseases associated with GIT are related to microbiota found in GIT, an imbalance of which causes gastrointestinal diseases. Probiotics, in light of scientific literature, are thought to play an important role in relieving symptoms of many diseases associated with GIT, i.e. beneficially regulating the microbiota composition. In the present review, we aimed to highlight the main considerations for main probiotic formulations to date. This study reviews the role of different probiotic formulations introduced so far in treating GI diseases in cohort ageing ≤18 years. We searched PubMed and Clinicaltrials.gov without any restrictions. This study comprises the descriptive and comparative analysis between Single-organism and Composite probiotics. These GI diseases include NEC, FAP, AGE, Acute Diarrhea, Ulcerative Colitis and etc. The results have been categorized according to title and outcomes. The positive outcomes emphasize the drug’s effectiveness in improving health and the negative outcome elaborates on the adverse effects the drug may have shown. Conclusively, discussed practices will assist in reducing GI disorders and strengthening the gut. Further insight into the various gut microbes and microbiomes with specific demographic is recommended.

Keywords

Probiotics; gut flora; gastrointestinal diseases; Lactobacillus; Bifidobacteria; placebo; Diarrhea; microbiota; composite; sin-gle-organisms; Ulcerative Colitis

Subject

Medicine and Pharmacology, Gastroenterology and Hepatology

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