Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Identification of Polymorphism Angiotensin Ii Type 1 Receptor (AT1) 1166 A/C Gene and Potassium Levels in Pre-Eclampsia among The Madurese Population

Version 1 : Received: 14 November 2022 / Approved: 16 November 2022 / Online: 16 November 2022 (01:47:26 CET)

How to cite: Zainiyah, Z.; Susanti, E.; Wulandari, N. Identification of Polymorphism Angiotensin Ii Type 1 Receptor (AT1) 1166 A/C Gene and Potassium Levels in Pre-Eclampsia among The Madurese Population. Preprints 2022, 2022110292. https://doi.org/10.20944/preprints202211.0292.v1 Zainiyah, Z.; Susanti, E.; Wulandari, N. Identification of Polymorphism Angiotensin Ii Type 1 Receptor (AT1) 1166 A/C Gene and Potassium Levels in Pre-Eclampsia among The Madurese Population. Preprints 2022, 2022110292. https://doi.org/10.20944/preprints202211.0292.v1

Abstract

Pre-eclampsia is a hypertension disorder during pregnancy, significantly affects maternal morbidity and mortality worldwide. A Case-control research was done on 100 pregnant mothers as respondents: 50 case (pre-eclampsia) and 50 control groups (healthy pregnant mothers). Selected case the following characteristics: were patients that visited the Syamrabu Bangkalan Public Hospital; were third-generation Madura natives; aged between 20-40 years old; had a gestational age of over 20mgg; had blood pressure above 140/90mmHg; and single pregnancies. Control had the following characteristics: were healthy pregnant women without pre-eclampsia or chronic hypertension; were third-generation Madura natives; had a gestational age of over 20mgg; aged between 20-40 years; and without pregnancy complications. The results showed of those with PE, 45 had the AA genotype (homozygote) (90%), five had AC (heterozygote) (8%) and one had CC (homozygote) (2%). As for those without PE, 33 had the AA genotype (homozygote) (73.3%), 11 had AC (heterozygote) (26.7%), none had CC (homozygote) (0%). PE and non-PE cases mostly had the AA genotype (homozygote) and A alleles. AT1R 1166 A/C polymorphism was found to be a significant risk factor for pre-eclampsia, while potassium level had no significant effect on it. Meaning further research is needed on different ethnicities and races.

Keywords

Preeclampsi; AT1; Pottasium; preeclampsi; Madurese

Subject

Medicine and Pharmacology, Obstetrics and Gynaecology

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