The fruits and leaves of the black currant (BC, Ribes nigrum) contain phytochemicals with thera-peutic benefits. The current paper reports on a standardized BC gemmotherapy extract (BC-GTE) prepared from fresh buds, and details the extract specific flavonoid content, antioxidant, and an-ti-inflammatory properties, respectively. The main HPLC identified aglyka flavonoids were lute-olin, quercetin, apigenin and kaempferol, while all together, at about 133 phytonutrients could be detected in the reported BC-GTE, so that the BC specific presence of many compounds was re-ported for the first time. We also demonstrated that in adult male Wistar rats pretreated with BC-GTE, and assessed after the LPS injection, the body size modifications of the activated microglial cells in the hippocampal CA1 region were not apparent, and no elevated serum specific TNF-α levels were seen under such LPS induced inflammatory conditions. The specific flavonoid content, and the LPS induced in-flammatory model based experimental data are all suggesting that the assessed BC-GTE seems to feature anti-neuroinflammatory property, holding the promise of a novel GTE based comple-mentary therapeutic approach.