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The Flavonoid Rich Black Currant (Ribes nigrum) Gemmotherapy Extract Prevents Microglial Body Swelling in Hippocampus and Reduces Serum TNF-α Level: Pilot Study
Version 1
: Received: 24 October 2022 / Approved: 27 October 2022 / Online: 27 October 2022 (11:17:04 CEST)
How to cite:
Téglás, T.; Mihok, E.; Cziáky, Z.; Oláh, N.; Nyakas, C.; Máthé, E. The Flavonoid Rich Black Currant (Ribes nigrum) Gemmotherapy Extract Prevents Microglial Body Swelling in Hippocampus and Reduces Serum TNF-α Level: Pilot Study. Preprints2022, 2022100435. https://doi.org/10.20944/preprints202210.0435.v1
Téglás, T.; Mihok, E.; Cziáky, Z.; Oláh, N.; Nyakas, C.; Máthé, E. The Flavonoid Rich Black Currant (Ribes nigrum) Gemmotherapy Extract Prevents Microglial Body Swelling in Hippocampus and Reduces Serum TNF-α Level: Pilot Study. Preprints 2022, 2022100435. https://doi.org/10.20944/preprints202210.0435.v1
Téglás, T.; Mihok, E.; Cziáky, Z.; Oláh, N.; Nyakas, C.; Máthé, E. The Flavonoid Rich Black Currant (Ribes nigrum) Gemmotherapy Extract Prevents Microglial Body Swelling in Hippocampus and Reduces Serum TNF-α Level: Pilot Study. Preprints2022, 2022100435. https://doi.org/10.20944/preprints202210.0435.v1
APA Style
Téglás, T., Mihok, E., Cziáky, Z., Oláh, N., Nyakas, C., & Máthé, E. (2022). The Flavonoid Rich Black Currant (<em>Ribes nigrum</em>) Gemmotherapy Extract Prevents Microglial Body Swelling in Hippocampus and Reduces Serum TNF-α Level: Pilot Study. Preprints. https://doi.org/10.20944/preprints202210.0435.v1
Chicago/Turabian Style
Téglás, T., Csaba Nyakas and Endre Máthé. 2022 "The Flavonoid Rich Black Currant (<em>Ribes nigrum</em>) Gemmotherapy Extract Prevents Microglial Body Swelling in Hippocampus and Reduces Serum TNF-α Level: Pilot Study" Preprints. https://doi.org/10.20944/preprints202210.0435.v1
Abstract
The fruits and leaves of the black currant (BC, Ribes nigrum) contain phytochemicals with thera-peutic benefits. The current paper reports on a standardized BC gemmotherapy extract (BC-GTE) prepared from fresh buds, and details the extract specific flavonoid content, antioxidant, and an-ti-inflammatory properties, respectively. The main HPLC identified aglyka flavonoids were lute-olin, quercetin, apigenin and kaempferol, while all together, at about 133 phytonutrients could be detected in the reported BC-GTE, so that the BC specific presence of many compounds was re-ported for the first time. We also demonstrated that in adult male Wistar rats pretreated with BC-GTE, and assessed after the LPS injection, the body size modifications of the activated microglial cells in the hippocampal CA1 region were not apparent, and no elevated serum specific TNF-α levels were seen under such LPS induced inflammatory conditions. The specific flavonoid content, and the LPS induced in-flammatory model based experimental data are all suggesting that the assessed BC-GTE seems to feature anti-neuroinflammatory property, holding the promise of a novel GTE based comple-mentary therapeutic approach.
Keywords
Ribes nigrum; Gemmotherapy; Neuroinflammation
Subject
Biology and Life Sciences, Cell and Developmental Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
