Omicron BA.2.75 Sublineage Follows the Expectations of the Evolution Theory: Less Negative Gibbs Energy of Biosynthesis Indicates Decreased Pathogenicity

Marko Popovic

doi:10.20944/preprints202210.0386.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 25 October 2022 / Approved: 25 October 2022 / Online: 25 October 2022 (10:53:13 CEST)

SARS-CoV-2 belongs to the group of RNA viruses with a pronounced tendency to mutate. Omicron BA.2.75 is a subvariant believed to be able to suppress the currently dominant BA.5. Omicron BA.2.75 is characterized by a greater infectivity compared to earlier Omicron variants. However, Gibbs energy of biosynthesis of virus particles is slightly less negative compared to those of other variants. Thus, the multiplication rate of Omicron BA.2.75 is lower than that of other variants. This leads to slower accumulation of newly formed virions and less damage to host cells, indicating evolution of SARS-CoV-2 towards decreasing pathogenicity.

COVID-19; SARS-CoV-2; Pandemic; Empirical formula; Growth stoichiometry; Thermodynamic properties of biosynthesis; Multiplication rate; Enthalpy; Entropy; Gibbs energy

Biology and Life Sciences, Biophysics

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Omicron BA.2.75 Sublineage Follows the Expectations of the Evolution Theory: Less Negative Gibbs Energy of Biosynthesis Indicates Decreased Pathogenicity

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