Version 1
: Received: 21 September 2022 / Approved: 23 September 2022 / Online: 23 September 2022 (10:23:51 CEST)
How to cite:
Bender, C.; Candi, I.; Rogel, E. Bioefficacy of Hydroxytyrosol-Rich Food Supplements on Preventing Lipid Peroxidation in Healthy Men. Preprints2022, 2022090371. https://doi.org/10.20944/preprints202209.0371.v1
Bender, C.; Candi, I.; Rogel, E. Bioefficacy of Hydroxytyrosol-Rich Food Supplements on Preventing Lipid Peroxidation in Healthy Men. Preprints 2022, 2022090371. https://doi.org/10.20944/preprints202209.0371.v1
Bender, C.; Candi, I.; Rogel, E. Bioefficacy of Hydroxytyrosol-Rich Food Supplements on Preventing Lipid Peroxidation in Healthy Men. Preprints2022, 2022090371. https://doi.org/10.20944/preprints202209.0371.v1
APA Style
Bender, C., Candi, I., & Rogel, E. (2022). Bioefficacy of Hydroxytyrosol-Rich Food Supplements on Preventing Lipid Peroxidation in Healthy Men. Preprints. https://doi.org/10.20944/preprints202209.0371.v1
Chicago/Turabian Style
Bender, C., Ilaria Candi and Eva Rogel. 2022 "Bioefficacy of Hydroxytyrosol-Rich Food Supplements on Preventing Lipid Peroxidation in Healthy Men" Preprints. https://doi.org/10.20944/preprints202209.0371.v1
Abstract
In the present study we report the efficacy of food matrices derived from olives in preventing oxidation of low-density lipoprotein cholesterol (LDL) and lipid peroxidation. To this end, 12 healthy volunteers were divided into 3 groups and cross-received a single dose of olive phenolics, mainly hydroxytyrosol (HT), provided as a liquid dietary supplement (30.6 or 61.5 mg HT), or as fortified extra virgin olive oil (12.19 mg HT + tyrosol). Blood and urine samples were collected at baseline and up to 12 hours after ingestion. Plasma oxidized LDL levels were measured by ELISA using a monoclonal antibody, while F2-isoprostanes were quantified in urine by UHPLC-MS/MS. Despite the great variability between individuals, a tendency to reduce lipoxidation reactions has been observed after olive phenolics intake in both, blood and urine. In addition, the subgroup of individuals with the highest baseline lipoxidation level showed a decrease in F2-isoprostanes (p < 0.05) after taking the food supplements, as well as a marked decrease in oxidized LDL levels (p < 0.01) after intake of the food supplement with the lowest HT dose. These promising results suggest that HT supplementation could be a useful aid in preventing lipoxidation. Additionally, people with a redox imbalance could benefit even more from supplementing with bioavailable HT.
Medicine and Pharmacology, Pharmacology and Toxicology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
