Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Bioefficacy of Hydroxytyrosol-Rich Food Supplements on Preventing Lipid Peroxidation in Healthy Men

Version 1 : Received: 21 September 2022 / Approved: 23 September 2022 / Online: 23 September 2022 (10:23:51 CEST)

How to cite: Bender, C.; Candi, I.; Rogel, E. Bioefficacy of Hydroxytyrosol-Rich Food Supplements on Preventing Lipid Peroxidation in Healthy Men. Preprints 2022, 2022090371 (doi: 10.20944/preprints202209.0371.v1). Bender, C.; Candi, I.; Rogel, E. Bioefficacy of Hydroxytyrosol-Rich Food Supplements on Preventing Lipid Peroxidation in Healthy Men. Preprints 2022, 2022090371 (doi: 10.20944/preprints202209.0371.v1).

Abstract

In the present study we report the efficacy of food matrices derived from olives in preventing oxidation of low-density lipoprotein cholesterol (LDL) and lipid peroxidation. To this end, 12 healthy volunteers were divided into 3 groups and cross-received a single dose of olive phenolics, mainly hydroxytyrosol (HT), provided as a liquid dietary supplement (30.6 or 61.5 mg HT), or as fortified extra virgin olive oil (12.19 mg HT + tyrosol). Blood and urine samples were collected at baseline and up to 12 hours after ingestion. Plasma oxidized LDL levels were measured by ELISA using a monoclonal antibody, while F2-isoprostanes were quantified in urine by UHPLC-MS/MS. Despite the great variability between individuals, a tendency to reduce lipoxidation reactions has been observed after olive phenolics intake in both, blood and urine. In addition, the subgroup of individuals with the highest baseline lipoxidation level showed a decrease in F2-isoprostanes (p < 0.05) after taking the food supplements, as well as a marked decrease in oxidized LDL levels (p < 0.01) after intake of the food supplement with the lowest HT dose. These promising results suggest that HT supplementation could be a useful aid in preventing lipoxidation. Additionally, people with a redox imbalance could benefit even more from supplementing with bioavailable HT.

Keywords

olive phenolics; hydroxytyrosol; oxidized LDL; ox-LDL; isoprostanes; F2-isoprostanes

Subject

MEDICINE & PHARMACOLOGY, Pharmacology & Toxicology

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.

We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.