Fatty Acid Metabolism in Endothelial Cell

Bin Liu; Zhiyu Dai

doi:10.20944/preprints202209.0095.v1

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preprints.org > biology and life sciences > anatomy and physiology > doi: 10.20944/preprints202209.0095.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Fatty Acid Metabolism in Endothelial Cell

Bin Liu

and

Zhiyu Dai

Version 1 : Received: 3 September 2022 / Approved: 7 September 2022 / Online: 7 September 2022 (03:11:51 CEST)
Version 2 : Received: 26 November 2022 / Approved: 28 November 2022 / Online: 28 November 2022 (02:22:27 CET)

A peer-reviewed article of this Preprint also exists.

Liu, B.; Dai, Z. Fatty Acid Metabolism in Endothelial Cell. Genes 2022, 13, 2301. Liu, B.; Dai, Z. Fatty Acid Metabolism in Endothelial Cell. Genes 2022, 13, 2301.

Abstract

The endothelium is a monolayer of cells lining the inner of blood and lymphatic vessels. Endothelial cells (ECs) release subtracts that prevent platelet and leukocyte adhesion and aggregation and modulate blood flow, which is essential for the normal function of the vascular system. ECs play indispensable roles in angiogenesis, homeostasis, stimulus or immune response under normal physiological conditions and its dysfunction is closely associated with pathologies such as cancer, diabetes, and pulmonary hypertension. Abnormal EC metabolism, especially fatty acid dysfunctional metabolism, contributes to the leading causes of pulmonary diseases. Expanding the knowledge of ECs’ dysfunctional metabolism in disease could pave a new way for new therapeutic approaches. In this review, we focus on discussing the latest advances in EC fatty acid metabolism in health and disease, with emphasis on its roles in the pathology of pulmonary hypertension (PH).

Keywords

endothelium; vascular biology; lipid; angiogenesis

Subject

Biology and Life Sciences, Anatomy and Physiology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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