Fatty Acid Metabolism in Endothelial Cell

Bin Liu; Zhiyu Dai

doi:10.20944/preprints202209.0095.v2

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preprints.org > biology and life sciences > anatomy and physiology > doi: 10.20944/preprints202209.0095.v2

Preprint Review Version 2 Preserved in Portico This version is not peer-reviewed

Fatty Acid Metabolism in Endothelial Cell

Bin Liu

and

Zhiyu Dai

Version 1 : Received: 3 September 2022 / Approved: 7 September 2022 / Online: 7 September 2022 (03:11:51 CEST)
Version 2 : Received: 26 November 2022 / Approved: 28 November 2022 / Online: 28 November 2022 (02:22:27 CET)

A peer-reviewed article of this Preprint also exists.

Liu, B.; Dai, Z. Fatty Acid Metabolism in Endothelial Cell. Genes 2022, 13, 2301. Liu, B.; Dai, Z. Fatty Acid Metabolism in Endothelial Cell. Genes 2022, 13, 2301.

Abstract

The endothelium is a monolayer of cells lining the inner blood vessels. Endothelial cells (ECs) play indispensable roles in angiogenesis, homeostasis, and immune response under normal physiological conditions, and their dysfunction is closely associated with pathologies such as cardiovascular diseases. Abnormal EC metabolism, especially fatty acid (FA) dysfunctional metabolism, contributes to the development of many diseases including pulmonary hypertension (PH). In this review, we focus on discussing the latest advances in FA metabolism in ECs under normal and pathological conditions with an emphasis on PH. We also highlight areas of research that warrant further investigation.

Keywords

endothelium; vascular biology; lipid; angiogenesis

Subject

Biology and Life Sciences, Anatomy and Physiology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Comments (1)

Comment 1

Received: 28 November 2022
Commenter: Zhiyu Dai
Commenter's Conflict of Interests: Author

Comment: Revision of review based on the reviewers' suggestion.

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