Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

The First Finding of Francisella Tularensis Subsp. Mediasiatica in Krasnoyarsk Territory, Siberia and an Update of the Subspecies Genetic Diversity

Vitalii Timofeev
* ORCID logo ,
Irina Bakhteeva
ORCID logo ,
Alexander Mokrievich
,
Galina Vakhrameeva
,
Elena Gritskova
,
Yuriy Anisimov
,
Evgeny Rozhdestvensky
,
Galina Bazarova
,
Rostislav Zhumakaev
,
Ivan Dyatlov
,
Gilles Vergnaud
*
Version 1 : Received: 2 September 2022 / Approved: 6 September 2022 / Online: 6 September 2022 (02:31:16 CEST)

A peer-reviewed article of this Preprint also exists.

Timofeev, V.; Bakhteeva, I.; Mokrievich, A.; Vakhrameeva, G.; Gritskova, E.; Anisimov, Y.; Rozhdestvensky, E.; Bazarova, G.; Zhumakaev, R.; Dyatlov, I.; Vergnaud, G. The First Finding of Francisella tularensis subsp. mediasiatica in Krasnoyarsk Territory, Siberia, and an Update of the Subspecies Genetic Diversity. Bacteria 2022, 1, 242-249. Timofeev, V.; Bakhteeva, I.; Mokrievich, A.; Vakhrameeva, G.; Gritskova, E.; Anisimov, Y.; Rozhdestvensky, E.; Bazarova, G.; Zhumakaev, R.; Dyatlov, I.; Vergnaud, G. The First Finding of Francisella tularensis subsp. mediasiatica in Krasnoyarsk Territory, Siberia, and an Update of the Subspecies Genetic Diversity. Bacteria 2022, 1, 242-249.

Abstract

Tularemia is a severe infectious disease caused by the Gram-negative bacteria Francisella tularensis. F. tularensis is currently divided into three subspecies, holarctica, tularensis and mediasiatica which differ in their virulence and geographic distribution. Subspecies mediasiatica is the least studied because of its very low documented virulence for humans and limited geographic distribution. It was discovered in sparsely populated regions of Central Asia. Since 2011, a new subsp. mediasiatica lineage was identified in Altai (Russia). In 2021, we isolated one subsp. mediasiatica strain in Krasnoyarsk Territory. In spite of its geographic origin, 500 km east from Altai, this strain belongs to the Altai lineage and contributes surprisingly little genetic diversity to previous knowledge. This improved knowledge of the phylogeography of subsp. mediasiatica led us to propose a scenario in which the two zoonotic lineages, holarctica and tularensis, independently emerged from the mediasiatica lineage in Siberia or Central Asia, and make predictions which will allow to challenge this hypothesis

Keywords

Francisella tularensis; subsp. mediasiatica; phylogeography; evolution

Subject

Biology and Life Sciences, Ecology, Evolution, Behavior and Systematics

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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