Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

The Role of Matrix Metalloproteinase in Infectious Diseases

Version 1 : Received: 26 August 2022 / Approved: 29 August 2022 / Online: 29 August 2022 (10:43:53 CEST)

A peer-reviewed article of this Preprint also exists.

Lee, H.S.; Kim, W.J. The Role of Matrix Metalloproteinase in Inflammation with a Focus on Infectious Diseases. Int. J. Mol. Sci. 2022, 23, 10546. Lee, H.S.; Kim, W.J. The Role of Matrix Metalloproteinase in Inflammation with a Focus on Infectious Diseases. Int. J. Mol. Sci. 2022, 23, 10546.

Journal reference: Int. J. Mol. Sci. 2022, 23, 10546
DOI: 10.3390/ijms231810546

Abstract

Matrix metalloproteinases are involved in extracellular matrix remodeling through the degradation of extracellular matrix components and are involved in the inflammatory response by regulating the activities of TNF-alpha and IL-1beta, which are pro-inflammatory cytokines, in addition to extracellular matrix components. Since the regulation of inflammatory response and changes in the extracellular matrix by MMPs are related to the development of various diseases including lung and cardiovascular diseases, many studies have been conducted on the role of MMPs in pathogenesis. In addition, various studies have demonstrated that MMPs are involved in the pathogenesis of infectious diseases by regulating the expression and activity of MMPs by infection with pathogens. In this review, we discuss the role of MMPs in infectious diseases and the role of MMPs in inflammatory responses and present their potential as therapeutic targets in infectious diseases.

Keywords

Influenza A virus; SARS-COV-2; matrix metalloproteinases; infectious diseases

Subject

BIOLOGY, Other

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