Chronic Positive Mass Balance is the Actual Etiology of Obesity: Time for A Paradigm Shift?

Anssi Manninen

doi:10.20944/preprints202208.0309.v1

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preprints.org > medicine and pharmacology > dietetics and nutrition > doi: 10.20944/preprints202208.0309.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Chronic Positive Mass Balance is the Actual Etiology of Obesity: Time for A Paradigm Shift?

Anssi Manninen

Version 1 : Received: 12 August 2022 / Approved: 17 August 2022 / Online: 17 August 2022 (08:45:00 CEST)
Version 2 : Received: 22 August 2022 / Approved: 23 August 2022 / Online: 23 August 2022 (03:35:09 CEST)
Version 3 : Received: 25 August 2022 / Approved: 26 August 2022 / Online: 26 August 2022 (03:33:17 CEST)
Version 4 : Received: 29 August 2022 / Approved: 29 August 2022 / Online: 29 August 2022 (10:40:44 CEST)
Version 5 : Received: 1 September 2022 / Approved: 2 September 2022 / Online: 2 September 2022 (03:30:54 CEST)
Version 6 : Received: 4 September 2022 / Approved: 5 September 2022 / Online: 5 September 2022 (05:15:15 CEST)
Version 7 : Received: 9 September 2022 / Approved: 13 September 2022 / Online: 13 September 2022 (03:08:59 CEST)
Version 8 : Received: 13 September 2022 / Approved: 14 September 2022 / Online: 14 September 2022 (03:21:21 CEST)
Version 9 : Received: 15 September 2022 / Approved: 16 September 2022 / Online: 16 September 2022 (03:18:08 CEST)
Version 10 : Received: 21 September 2022 / Approved: 21 September 2022 / Online: 21 September 2022 (09:57:44 CEST)
Version 11 : Received: 28 September 2022 / Approved: 29 September 2022 / Online: 29 September 2022 (03:02:54 CEST)
Version 12 : Received: 17 October 2022 / Approved: 18 October 2022 / Online: 18 October 2022 (04:11:20 CEST)

A peer-reviewed article of this Preprint also exists.

H Manninen, A. Chronic Positive Mass Balance Is the Actual Etiology of Obesity: A Living Review. Global Translational Medicine, 2023, 2, 222. https://doi.org/10.36922/gtm.222. H Manninen, A. Chronic Positive Mass Balance Is the Actual Etiology of Obesity: A Living Review. Global Translational Medicine, 2023, 2, 222. https://doi.org/10.36922/gtm.222.

Abstract

According to known laws of physics, chronic positive mass balance is the actual etiology of obesity, not positive energy balance. The relevant physical law in terms of body mass regulation is the Law of Conservation of Mass, not the Law of Conservation of Energy. A recently proposed mass balance model (MBM) describes the temporal evolution of body weight and body composition under a wide variety of feeding experiments, and it seems to provide a highly accurate description of the very best human experimental feeding data. By shifting to a mass balance paradigm of obesity, a deeper understanding of this disease may follow in the near future.

Keywords

energy balance theory; mass balance model; body weight regulation

Subject

Medicine and Pharmacology, Dietetics and Nutrition

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Comments (4)

Comment 1

Received: 17 August 2022
Commenter: Hal Emmerich, PhD
The commenter has declared there is no conflict of interests.

Comment: I have a question concerning your theory.

If person's weight remains stable on a diet when consuming 400g of carbohydrates, 50g of fat and 150g of protein, what would then happen if this person changed his diet to 50g of carbohydrates, 400g of fat and 150g of protein. Based on your theory the weight should remain the same?

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Comment 2

Received: 17 August 2022
Commenter:

Anssi H. Manninen

The commenter has declared there is no conflict of interests.

Comment: Dear Dr. Emmerich,

I recommend reading the key references mentioned in the article.

All the best,

Anssi H. Manninen

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Comment 3

Received: 20 August 2022
Commenter: Melon Usk
The commenter has declared there is no conflict of interests.

Comment: Is Francisco still involved in this project?

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Comment 4

Received: 21 August 2022
Commenter:

Anssi H. Manninrn

The commenter has declared there is no conflict of interests.

Comment: A recent paper of interest:

https://www.sciencedirect.com/science/article/pii/S0022519322002351?via%3Dihub
The energy balance theory ("Calories In, Calories Out") is indeed a flawed paradigm.

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