Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Relationship between Coronary Arterial Geometry and the Presence and Extend of Atherosclerotic Plaque Burden: A Review Discussing Methodology and Findings in the Era of Cardiac Computed Tomography Angiography

Georgios Rampidis
* ORCID logo ,
Vasileios Rafailidis
,
Konstantinos Kouskouras
,
Andjoli Davidhi
,
Angeliki Papachristodoulou
,
Athanasios Samaras
,
George Giannakoulas
,
Antonios Ziakas
,
Panagiotis Prassopoulos
,
Haralambos Karvounis
Version 1 : Received: 13 August 2022 / Approved: 17 August 2022 / Online: 17 August 2022 (03:24:46 CEST)

A peer-reviewed article of this Preprint also exists.

Rampidis, G.; Rafailidis, V.; Kouskouras, K.; Davidhi, A.; Papachristodoulou, A.; Samaras, A.; Giannakoulas, G.; Ziakas, A.; Prassopoulos, P.; Karvounis, H. Relationship between Coronary Arterial Geometry and the Presence and Extend of Atherosclerotic Plaque Burden: A Review Discussing Methodology and Findings in the Era of Cardiac Computed Tomography Angiography. Diagnostics 2022, 12, 2178. Rampidis, G.; Rafailidis, V.; Kouskouras, K.; Davidhi, A.; Papachristodoulou, A.; Samaras, A.; Giannakoulas, G.; Ziakas, A.; Prassopoulos, P.; Karvounis, H. Relationship between Coronary Arterial Geometry and the Presence and Extend of Atherosclerotic Plaque Burden: A Review Discussing Methodology and Findings in the Era of Cardiac Computed Tomography Angiography. Diagnostics 2022, 12, 2178.

Abstract

Coronary artery disease (CAD) represents a modern pandemic associated with significant morbidity and mortality. The multi-faceted pathogenesis of this entity has long been investigated, highlighting the contribution of systemic factors such as hyperlipidemia and hypertension. Nevertheless, recent research has drawn light to the importance of geometrical features of coronary vasculature on the complexity and vulnerability of coronary atherosclerosis. Various parameters have been investigated so far, including vessel-length, cross-sectional area, curvature, and tortuosity, using primarily invasive angiography and recently non-invasive cardiac computed tomography angiography (CCTA). It is clear that there is correlation between geometrical parameters and both the haemodynamic alterations augmenting the atherosclerosis-prone environment and the extent of plaque burden. The purpose of this review is to discuss the currently available literature regarding this issue and propose a potential non-invasive imaging biomarker, the geometric risk score, which could be of importance to allow early detection of individuals at increased risk of developing CAD.

Keywords

coronary; atherosclerosis; cardiac CT; geometry

Subject

Medicine and Pharmacology, Cardiac and Cardiovascular Systems

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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