Lipofuscin and Aging: Testing the Garbage Catastrophe Theory in cellulo

Michael Renteln

doi:10.20944/preprints202208.0229.v7

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preprints.org > biology and life sciences > life sciences > doi: 10.20944/preprints202208.0229.v7

Preprint Review Version 7 Preserved in Portico This version is not peer-reviewed

Lipofuscin and Aging: Testing the Garbage Catastrophe Theory in cellulo

Michael Renteln

Version 1 : Received: 11 August 2022 / Approved: 12 August 2022 / Online: 12 August 2022 (08:05:09 CEST)
Version 2 : Received: 20 September 2022 / Approved: 21 September 2022 / Online: 21 September 2022 (03:36:55 CEST)
Version 3 : Received: 26 September 2022 / Approved: 27 September 2022 / Online: 27 September 2022 (04:20:31 CEST)
Version 4 : Received: 27 October 2022 / Approved: 28 October 2022 / Online: 28 October 2022 (05:21:13 CEST)
Version 5 : Received: 2 November 2022 / Approved: 2 November 2022 / Online: 2 November 2022 (03:41:32 CET)
Version 6 : Received: 19 March 2023 / Approved: 20 March 2023 / Online: 20 March 2023 (03:43:19 CET)
Version 7 : Received: 6 September 2023 / Approved: 6 September 2023 / Online: 7 September 2023 (03:36:15 CEST)
Version 8 : Received: 4 April 2024 / Approved: 5 April 2024 / Online: 8 April 2024 (13:40:34 CEST)

How to cite: Renteln, M. Lipofuscin and Aging: Testing the Garbage Catastrophe Theory in cellulo. Preprints 2022, 2022080229. https://doi.org/10.20944/preprints202208.0229.v7 Renteln, M. Lipofuscin and Aging: Testing the Garbage Catastrophe Theory in cellulo. Preprints 2022, 2022080229. https://doi.org/10.20944/preprints202208.0229.v7

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MDPI and ACS Style

Renteln, M. Lipofuscin and Aging: Testing the Garbage Catastrophe Theory in cellulo. Preprints 2022, 2022080229. https://doi.org/10.20944/preprints202208.0229.v7

APA Style

Renteln, M. (2023). Lipofuscin and Aging: Testing the Garbage Catastrophe Theory in cellulo. Preprints. https://doi.org/10.20944/preprints202208.0229.v7

Chicago/Turabian Style

Renteln, M. 2023 "Lipofuscin and Aging: Testing the Garbage Catastrophe Theory in cellulo" Preprints. https://doi.org/10.20944/preprints202208.0229.v7

Abstract

Lipofuscin is indigestible garbage that accumulates in the autophagic vesicles and cytosol of post-mitotic cells with age. Drs. Brunk and Terman postulated that lipofuscin accumulation is the main or at least a major driving factor in aging. They even posited that the evolution of memory is the reason why we get lipofuscin at all, as stable synaptic connections must be maintained over time, meaning that the somas of neurons must also remain in the same locale. In other words, they cannot dilute out their garbage over time through cell division. Mechanistically, their position certainly makes sense given that rendering a large percentage of a post-mitotic cell’s lysosomes useless must almost certainly negatively affect that cell and the surrounding microenvironment. Here, I explore the possibility that the accumulation of lipofuscin may to some extent exacerbate every other kind of age-related damage. I do not think that lipofuscin removal will reverse/prevent all forms of aging, just the major component facing us currently. In this piece, I will review what is known about lipofuscin accumulation from evolutionary and mechanistic standpoints and discuss a method of removing it from single cells in vitro.

Keywords

Anti-aging; Hydra vulgaris; TFEB; telomerase; FluidFM

Subject

Biology and Life Sciences, Life Sciences

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Comments (1)

Comment 1

Received: 7 September 2023
Commenter: Michael Renteln
Commenter's Conflict of Interests: Author

Comment: This article is now focused on the evolutionary and mechanistic evidence for the garbage catastrophe theory of aging and a method of testing said theory in vitro involving FluidFM.

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