ayoub, maha abdulmajeed Effects of Flavonoids on Cholesterol Efflux Capability. International Journal of Medical Biochemistry 2022, doi:10.14744/ijmb.2022.96977.
ayoub, maha abdulmajeed Effects of Flavonoids on Cholesterol Efflux Capability. International Journal of Medical Biochemistry 2022, doi:10.14744/ijmb.2022.96977.
ayoub, maha abdulmajeed Effects of Flavonoids on Cholesterol Efflux Capability. International Journal of Medical Biochemistry 2022, doi:10.14744/ijmb.2022.96977.
ayoub, maha abdulmajeed Effects of Flavonoids on Cholesterol Efflux Capability. International Journal of Medical Biochemistry 2022, doi:10.14744/ijmb.2022.96977.
Abstract
One of the mechanisms used in the management and cure of atherosclerosis is reverse cholesterol transfer (RCT), which plays a vital role in the export of cholesterol from peripheral cells. Cholesterol efflux from macrophages in the subintima of the vessel wall is a critical part of RCT. ATP-binding cassette transporter A1 (ABCA1) and ATP-binding cassette transporter G1 (ABCG1) are involved in the transfer of cholesterol from arterial macrophages to extracellular high-density lipoprotein cholesterol (HDL). The HDL then transports esterified cholesterol to the liver for elimination. An important factor in the reverse cholesterol transport and excretion of extracellular cholesterol is HDL. Atherogenesis can be prevented by altering the processes of RCT and cholesterol efflux, and this might lead to novel treatment options for cardiovascular disease. Research of novel modifying variables for RCT and cholesterol efflux is necessary. A better understanding of RCT's molecular processes has been gained via research, allowing for the creation of new treatments that make use of RCT's potential for pharmacological improvement. The purpose of this review is to provoke discussion on the potential impact of selected flavonoids on cholesterol efflux on the progression of atherosclerosis (Fig. 1.).
Keywords
Cholesterol efflux; flavonoids; HDL; quercetin; reverse cholesterol transport
Subject
Medicine and Pharmacology, Cardiac and Cardiovascular Systems
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
