Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

pH-Sensitive Polyacrylic Acid-Gated Mesoporous Silica Nanocarrier Incorporated with Calcium Ions for Controlled Drug Release

Version 1 : Received: 1 August 2022 / Approved: 2 August 2022 / Online: 2 August 2022 (12:15:03 CEST)

How to cite: Kong, J.; Park, S.S.; Ha, C. pH-Sensitive Polyacrylic Acid-Gated Mesoporous Silica Nanocarrier Incorporated with Calcium Ions for Controlled Drug Release. Preprints 2022, 2022080066 (doi: 10.20944/preprints202208.0066.v1). Kong, J.; Park, S.S.; Ha, C. pH-Sensitive Polyacrylic Acid-Gated Mesoporous Silica Nanocarrier Incorporated with Calcium Ions for Controlled Drug Release. Preprints 2022, 2022080066 (doi: 10.20944/preprints202208.0066.v1).

Abstract

In this work, polyacrylic acid-functionalized MCM-41 was synthesized, which was further interacted with calcium ions, to realize enhanced pH-responsive nanocarrier for sustained drug release. First, mesoporous silica nanoparticles (MSNs) were prepared by the sol-gel method. Afterward, (3-trimethoxysilyl)propyl methacrylate (TMSPM) modified surface was prepared by using the post-grafting method, then polymerization of acrylic acid was proceeded. After adding calcium chloride solution, polyacrylic acid-functionalized MSNs with calcium-carboxyl ionic bonds in the polymeric layer, which can prevent the cargo from leaking out of the mesopore, were prepared. The structure and morphology of the modified nanoparticles (PAA-MSNs) were characterized by X-ray diffraction (XRD), Fourier-transform infrared (FT-IR) spectroscopy, transmission electron microscopy (TEM), and N2 adsorption-desorption analysis, etc. The controlled release of guest molecules was studied by using 5-fluorouracil (5-FU). The drug molecules-incorporated nanoparticles showed different releasing rates under different pH conditions. It is considered that our current materials have the potential as pH-responsive targeted nanocarriers in the field of medical treatment.

Keywords

Mesoporous silica; Polyacrylic acid; Calcium ion; 5-Fluorouracil; Drug delivery

Subject

MATERIALS SCIENCE, Biomaterials

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