Associated Risk Factors and Pathogen Burden among ICU Patients in a Tertiary Care Hospital in Hail Saudi Arabia with Particular Reference to β-Lactamases Profile

Saleem Mohd; Azharuddin Sajid Syed Khaja; Ashfaque Hossain; Fahaad Alenazi; Kamaleldin B Said; Soha Abdallah Moursi; Homoud Abdulmohsin Almalaq; Hamza Mohamed; Ehab Rakha; Mohammed Salem Alharbi; Kauser Usman

doi:10.20944/preprints202207.0459.v1

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preprints.org > life sciences > microbiology > doi: 10.20944/preprints202207.0459.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Associated Risk Factors and Pathogen Burden among ICU Patients in a Tertiary Care Hospital in Hail Saudi Arabia with Particular Reference to β-Lactamases Profile

Saleem Mohd

Azharuddin Sajid Syed Khaja

^* ,

Homoud Abdulmohsin Almalaq

Hamza Mohamed

Ehab Rakha

Mohammed Salem Alharbi

Kauser Usman

Version 1 : Received: 27 July 2022 / Approved: 29 July 2022 / Online: 29 July 2022 (10:15:38 CEST)

How to cite: Mohd, S.; Syed Khaja, A.S.; Hossain, A.; Alenazi, F.; Said, K.B.; Moursi, S.A.; Almalaq, H.A.; Mohamed, H.; Rakha, E.; Salem Alharbi, M.; Usman, K. Associated Risk Factors and Pathogen Burden among ICU Patients in a Tertiary Care Hospital in Hail Saudi Arabia with Particular Reference to β-Lactamases Profile. Preprints 2022, 2022070459. https://doi.org/10.20944/preprints202207.0459.v1. Mohd, S.; Syed Khaja, A.S.; Hossain, A.; Alenazi, F.; Said, K.B.; Moursi, S.A.; Almalaq, H.A.; Mohamed, H.; Rakha, E.; Salem Alharbi, M.; Usman, K. Associated Risk Factors and Pathogen Burden among ICU Patients in a Tertiary Care Hospital in Hail Saudi Arabia with Particular Reference to β-Lactamases Profile. Preprints 2022, 2022070459. https://doi.org/10.20944/preprints202207.0459.v1.

Cite as:

Mohd, S.; Syed Khaja, A.S.; Hossain, A.; Alenazi, F.; Said, K.B.; Moursi, S.A.; Almalaq, H.A.; Mohamed, H.; Rakha, E.; Salem Alharbi, M.; Usman, K. Associated Risk Factors and Pathogen Burden among ICU Patients in a Tertiary Care Hospital in Hail Saudi Arabia with Particular Reference to β-Lactamases Profile. Preprints 2022, 2022070459. https://doi.org/10.20944/preprints202207.0459.v1. Mohd, S.; Syed Khaja, A.S.; Hossain, A.; Alenazi, F.; Said, K.B.; Moursi, S.A.; Almalaq, H.A.; Mohamed, H.; Rakha, E.; Salem Alharbi, M.; Usman, K. Associated Risk Factors and Pathogen Burden among ICU Patients in a Tertiary Care Hospital in Hail Saudi Arabia with Particular Reference to β-Lactamases Profile. Preprints 2022, 2022070459. https://doi.org/10.20944/preprints202207.0459.v1.

Abstract

A 1-year prospective study was carried out on patients in the ICU unit at a tertiary care hospital, Hail, Kingdom of Saudi Arabia. A total of 163 bacterial isolates were obtained from different clinical specimens with a high proportion of bacteria found associated with ventilator-associated pneumoniae (70, 43%), followed by catheter-associated urinary tract infection (39, 24%), central line-associated bloodstream infection (25, 15%), and surgical site infection (14, 8.6%). Klebsiella pneumoniae was the most common isolate (39, 24%), followed by Acinetobacter baumannii (35, 21.47%), Pseudomonas aeruginosa (25, 15%), and Proteus spp (23, 14%). Among the highly prevalent bacterial isolates, extended-spectrum beta-lactamase was predominant (42, 42.4%). Proper use of antibiotics, continuous monitoring of drug sensitivity patterns, and taking all precautionary measures to prevent beta-lactamases-producing organisms in the clinical settings are crucial and significant factors to fend off life-threatening infections and for a better outcome.

Keywords

ICU; VAP; ESBL; Klebsiella pneumoniae; Acinetobacter baumannii

Subject

LIFE SCIENCES, Microbiology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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