Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Information Theory as an Experimental Tool for Integrating Disparate Biophysical Signaling Modules

Version 1 : Received: 20 July 2022 / Approved: 25 July 2022 / Online: 25 July 2022 (12:35:28 CEST)

A peer-reviewed article of this Preprint also exists.

McMillen, P.; Walker, S.I.; Levin, M. Information Theory as an Experimental Tool for Integrating Disparate Biophysical Signaling Modules. Int. J. Mol. Sci. 2022, 23, 9580. McMillen, P.; Walker, S.I.; Levin, M. Information Theory as an Experimental Tool for Integrating Disparate Biophysical Signaling Modules. Int. J. Mol. Sci. 2022, 23, 9580.

Abstract

There is a growing appreciation in the fields of Cell and Developmental Biology that cells collectively process information in time and space. While many powerful molecular tools exist to observe biophysical dynamics biologists must find ways to quantitatively understand these phenomena at the systems level. Here, we present a guide for application of well-established information theory metrics to biological datasets and explain these metrics using examples from cell, developmental and regenerative biology. We introduce a novel computational tool (CAIM) for simple, rigorous application of these metrics to timeseries datasets. Finally, we use CAIM to study calcium and cytoskeletal Actin information flow patterns between Xenopus laevis embryonic animal cap stem cells. The tools that we present here will enable biologists to apply information theory to develop systems level understanding of a diverse array of experimental systems.

Keywords

information theory; embryogenesis; regeneration; cell biology; morphogenesis; calcium

Subject

Biology and Life Sciences, Cell and Developmental Biology

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.