Srinivasan Rajsri, K.; Rao, M. Poxvirus-Driven Human Diseases and Emerging Therapeutics. Therapeutic Advances in Infectious Disease, 2022, 9, 204993612211367. https://doi.org/10.1177/20499361221136751.
Srinivasan Rajsri, K.; Rao, M. Poxvirus-Driven Human Diseases and Emerging Therapeutics. Therapeutic Advances in Infectious Disease, 2022, 9, 204993612211367. https://doi.org/10.1177/20499361221136751.
Srinivasan Rajsri, K.; Rao, M. Poxvirus-Driven Human Diseases and Emerging Therapeutics. Therapeutic Advances in Infectious Disease, 2022, 9, 204993612211367. https://doi.org/10.1177/20499361221136751.
Srinivasan Rajsri, K.; Rao, M. Poxvirus-Driven Human Diseases and Emerging Therapeutics. Therapeutic Advances in Infectious Disease, 2022, 9, 204993612211367. https://doi.org/10.1177/20499361221136751.
Abstract
Poxviridae have been successful pathogens throughout recorded history, infecting humans among a variety of other hosts. Although eradication of the notorious smallpox has been a globally successful healthcare phenomenon, the recent emergence of Monkeypox virus, also belonging to the Orthopoxvirus genus and causing human disease, albeit milder than smallpox, is a cause of significant public health concern. The ongoing outbreak of monkeypox, demonstrating human-human transmission, in previously non-endemic countries, calls for critical need into further research in the areas of viral biology, ecology and epidemiology to better understand, prevent and treat human infections. In the wake of these recent events, it becomes important to revisit poxviral infections, their pathogenesis and ability to cause infection across multiple non-human hosts and leap to a human host. The poxviruses that cause human diseases include Monkeypox virus, Molluscum contagiosum virus and Orf virus. In this review we summarize the current understanding of various poxviruses causing human diseases, provide insights into their replication and pathogenicity, disease progression and symptoms, preventive and treatment options and their importance in shaping modern medicine through application in gene therapy, oncolytic viral therapies for human cancers or as poxvirus vectors for vaccines.
Medicine and Pharmacology, Epidemiology and Infectious Diseases
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received:
22 September 2022
Commenter:
Ricardo Salcedo
The commenter has declared there is no conflict of interests.
Comment:
Looks ibteresting butit is not possible to Open the PDF version after download. Maybe damaged archive. Flor Your Information. Thank You and Goodbye.
Commenter: Ricardo Salcedo
The commenter has declared there is no conflict of interests.