Andreini, C.; Rosato, A. Structural Bioinformatics and Deep Learning of Metalloproteins: Recent Advances and Applications. Int. J. Mol. Sci.2022, 23, 7684.
Andreini, C.; Rosato, A. Structural Bioinformatics and Deep Learning of Metalloproteins: Recent Advances and Applications. Int. J. Mol. Sci. 2022, 23, 7684.
Andreini, C.; Rosato, A. Structural Bioinformatics and Deep Learning of Metalloproteins: Recent Advances and Applications. Int. J. Mol. Sci.2022, 23, 7684.
Andreini, C.; Rosato, A. Structural Bioinformatics and Deep Learning of Metalloproteins: Recent Advances and Applications. Int. J. Mol. Sci. 2022, 23, 7684.
Abstract
All living organisms require some metal ions for their energy production as well as metabolic and biosynthetic processes. Within cells, metal ions are involved in the formation of adducts interact with metabolites and macromolecules (proteins and nucleic acids). The proteins that require binding to one or more metal ions to be able to carry out their physiological function are called metalloproteins. About one third of all protein structures in the Protein Data Bank involve metalloproteins. Over the past few years there has been a tremendous progress in the number of computational tools and techniques making use of 3D structural information to support the investigation of metalloproteins. This trend has been boosted also by the successful applications of neural networks and deep learning approaches in molecular and structural biology at large. In this review, we discuss recent advances in the development and availability of resources dealing with metalloproteins from a structure-based perspective. We start by addressing tools for the prediction of metal-binding sites (MBSs) using structural information on apo-proteins. Then, we provide an overview of methods for and lessons learned from the structural comparison of MBSs in a fold-independent manner. We then move to describing databases of metalloprotein/MBS structures. Finally, we summarize recent DL applications enhancing the functional interpretation of metalloprotein structures.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
