Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

The Current Status of Cigarette Smoking and Air Pollution Associated Lung Cancer

Version 1 : Received: 2 June 2022 / Approved: 6 June 2022 / Online: 6 June 2022 (03:51:38 CEST)

How to cite: Ma, F. The Current Status of Cigarette Smoking and Air Pollution Associated Lung Cancer . Preprints 2022, 2022060056 (doi: 10.20944/preprints202206.0056.v1). Ma, F. The Current Status of Cigarette Smoking and Air Pollution Associated Lung Cancer . Preprints 2022, 2022060056 (doi: 10.20944/preprints202206.0056.v1).

Abstract

Cigarette smoking and air pollution (particulate matter) are recognized as two major etiological factors for lung cancer. Of all the risk factors, cigarette smoking is significantly associated with lung carcinogenesis. The main mechanism lies in the metabolically activated carcinogens (majorly polycyclic aromatic hydrocarbons and nitrosamines), which could covalently bind with DNA molecules and lead to irreversible mutations in pivotal cancer genes, such as TP53 and KRAS. Another major etiological factor for lung cancer is air pollution, which is with complex compositions and ubiquitous in daily life, especially in developing countries as China and India. The latest literatures on lung cancer epidemiology and etiology have been briefly summarized and reviewed in this work.

Keywords

lung cancer; cigarette smoking; air pollution; epidemiology; etiology

Subject

LIFE SCIENCES, Other

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.

We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.