Preprint Essay Version 2 Preserved in Portico This version is not peer-reviewed

Allergy is an Immune Disorder Related to a Lack of Regulation: The Gluing Role of IL-2

Version 1 : Received: 24 May 2022 / Approved: 25 May 2022 / Online: 25 May 2022 (09:45:52 CEST)
Version 2 : Received: 9 November 2022 / Approved: 10 November 2022 / Online: 10 November 2022 (11:09:22 CET)

How to cite: Mengel, J. Allergy is an Immune Disorder Related to a Lack of Regulation: The Gluing Role of IL-2. Preprints 2022, 2022050345. https://doi.org/10.20944/preprints202205.0345.v2 Mengel, J. Allergy is an Immune Disorder Related to a Lack of Regulation: The Gluing Role of IL-2. Preprints 2022, 2022050345. https://doi.org/10.20944/preprints202205.0345.v2

Abstract

This manuscript provides a new integrated view of the development of allergen-specific TH2 and the lack of their associated Treg cells in a unified model, justifying the need for IL-2 to correct allergy conditions.

Keywords

allergy; regulatory T cells; IL-2; IL-4; Th2; tolerance

Subject

Biology and Life Sciences, Immunology and Microbiology

Comments (1)

Comment 1
Received: 10 November 2022
Commenter: Jose Mengel
Commenter's Conflict of Interests: Author
Comment:  The text was modified, arguing that Foxp3+ Tregs are involved in allergy amelioration promoted by immunotherapy. A brief discussion on possible mechanisms provided by allergen-specific Treg activation or IL-2 administration was added. I think the modifications and new references improved the manuscript.
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