Version 1
: Received: 24 May 2022 / Approved: 25 May 2022 / Online: 25 May 2022 (09:45:52 CEST)
Version 2
: Received: 9 November 2022 / Approved: 10 November 2022 / Online: 10 November 2022 (11:09:22 CET)
How to cite:
Mengel, J. Allergy is an Immune Disorder Related to a Lack of Regulation: The Gluing Role of IL-2. Preprints2022, 2022050345. https://doi.org/10.20944/preprints202205.0345.v2
Mengel, J. Allergy is an Immune Disorder Related to a Lack of Regulation: The Gluing Role of IL-2. Preprints 2022, 2022050345. https://doi.org/10.20944/preprints202205.0345.v2
Mengel, J. Allergy is an Immune Disorder Related to a Lack of Regulation: The Gluing Role of IL-2. Preprints2022, 2022050345. https://doi.org/10.20944/preprints202205.0345.v2
APA Style
Mengel, J. (2022). Allergy is an Immune Disorder Related to a Lack of Regulation: The Gluing Role of IL-2. Preprints. https://doi.org/10.20944/preprints202205.0345.v2
Chicago/Turabian Style
Mengel, J. 2022 "Allergy is an Immune Disorder Related to a Lack of Regulation: The Gluing Role of IL-2" Preprints. https://doi.org/10.20944/preprints202205.0345.v2
Abstract
This manuscript provides a new integrated view of the development of allergen-specific TH2 and the lack of their associated Treg cells in a unified model, justifying the need for IL-2 to correct allergy conditions.
Keywords
allergy; regulatory T cells; IL-2; IL-4; Th2; tolerance
Subject
Biology and Life Sciences, Immunology and Microbiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received:
10 November 2022
Commenter:
Jose Mengel
Commenter's Conflict of Interests:
Author
Comment:
The text was modified, arguing that Foxp3+ Tregs are involved in allergy amelioration promoted by immunotherapy. A brief discussion on possible mechanisms provided by allergen-specific Treg activation or IL-2 administration was added. I think the modifications and new references improved the manuscript.
Commenter: Jose Mengel
Commenter's Conflict of Interests: Author