The COVID-19 pandemic has caused significant medical and psychological challenges worldwide, and, in many cases, not only exceeded the capacity of hospitals and intensive care units (ICUs) but also an individuals’ ability to cope with life. Health-care workers have continued to provide care for patients despite exhaustion, fear of transmission to themselves and their family members, illness or death of friends and colleagues, and the loss of many patients. They have also faced many additional sources of stress and anxiety, and long shifts combined with unprecedented population restrictions, including personal isolation. This study digitally measured the psychological parameters of health care workers during the COVID-19 pandemic, followed by an app-based yoga of immortal (YOI) intervention. Participants in this study completed validated psychological measures including the Patient Health Questionnaire-8 (PHQ-8), Insomnia Severity Index (ISI) and generalized anxiety disorder (GAD-7) scales. The digital YOI intervention significantly reduced the anxiety, depression symptoms, and insomnia in healthcare workers.