Endocrine Disruptors in Food, Estrobolome and Breast Cancer

Alessio Filippone; Cristina Rossi; Maria Maddalena Rossi; Annalisa Di Micco; Claudia Maggiore; Luana Forcina; Maria Natale; Lara Costantini; Nicolò Merendino; Alba Di Leone; Gianluca Franceschini; Riccardo Masetti; Stefano Magno

doi:10.20944/preprints202205.0218.v1

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preprints.org > medicine & pharmacology > oncology & oncogenics > doi: 10.20944/preprints202205.0218.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Endocrine Disruptors in Food, Estrobolome and Breast Cancer

Alessio Filippone

^* ,

Cristina Rossi

Maria Maddalena Rossi

Gianluca Franceschini

Riccardo Masetti

Stefano Magno

Version 1 : Received: 16 May 2022 / Approved: 17 May 2022 / Online: 17 May 2022 (03:25:56 CEST)
Version 2 : Received: 9 March 2023 / Approved: 10 March 2023 / Online: 10 March 2023 (02:21:55 CET)

How to cite: Filippone, A.; Rossi, C.; Rossi, M.M.; Di Micco, A.; Maggiore, C.; Forcina, L.; Natale, M.; Costantini, L.; Merendino, N.; Di Leone, A.; Franceschini, G.; Masetti, R.; Magno, S. Endocrine Disruptors in Food, Estrobolome and Breast Cancer. Preprints 2022, 2022050218. https://doi.org/10.20944/preprints202205.0218.v1. Filippone, A.; Rossi, C.; Rossi, M.M.; Di Micco, A.; Maggiore, C.; Forcina, L.; Natale, M.; Costantini, L.; Merendino, N.; Di Leone, A.; Franceschini, G.; Masetti, R.; Magno, S. Endocrine Disruptors in Food, Estrobolome and Breast Cancer. Preprints 2022, 2022050218. https://doi.org/10.20944/preprints202205.0218.v1.

Cite as:

Filippone, A.; Rossi, C.; Rossi, M.M.; Di Micco, A.; Maggiore, C.; Forcina, L.; Natale, M.; Costantini, L.; Merendino, N.; Di Leone, A.; Franceschini, G.; Masetti, R.; Magno, S. Endocrine Disruptors in Food, Estrobolome and Breast Cancer. Preprints 2022, 2022050218. https://doi.org/10.20944/preprints202205.0218.v1. Filippone, A.; Rossi, C.; Rossi, M.M.; Di Micco, A.; Maggiore, C.; Forcina, L.; Natale, M.; Costantini, L.; Merendino, N.; Di Leone, A.; Franceschini, G.; Masetti, R.; Magno, S. Endocrine Disruptors in Food, Estrobolome and Breast Cancer. Preprints 2022, 2022050218. https://doi.org/10.20944/preprints202205.0218.v1.

Abstract

The microbiota is now recognized as one of the major players in human health and disease, in-cluding cancer. As regards breast cancer (BC), a clear link between microbiota and oncogenesis is still to be confirmed. Yet, part of the bacterial gene mass inside the gut, constituting the so called “estrobolome”, influences the sexual hormonal balance and, since the increased exposure to estrogens is associated with an increased risk, it may impact on the onset, progression, and treatment of hormonal dependent cancers, which account for more than 70% of all BCs. The hormonal dependent BCs are also affected by environmental and dietary endocrine disruptors and phytoestrogens which interact with microbiota in a bidirectional way: on one side disruptors can alter the composition and functions of the estrobolome, on the other the gut microbiota influences the metabolism of endocrine active food components. This review highlights the current evidence about the complex interplay between endocrine disruptors, phytoestrogens, microbiome, and BC, within the frames of a new “oncobiotic” perspective.

Keywords

Microbiome; Endocrine disruptors; Estrobolome; Personalized medicine; Oncobiotic

Subject

MEDICINE & PHARMACOLOGY, Oncology & Oncogenics

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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