Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Comprehensive Biotechnical System for Screening Risk-Based Diagnosis of COVID-19 and Post-COVID Syndrome

Version 1 : Received: 14 May 2022 / Approved: 17 May 2022 / Online: 17 May 2022 (03:13:32 CEST)
Version 2 : Received: 22 May 2022 / Approved: 23 May 2022 / Online: 23 May 2022 (05:26:58 CEST)

A peer-reviewed article of this Preprint also exists.

{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,1,15]],"date-time":"2023-01-15T06:14:14Z","timestamp":1673763254764},"reference-count":29,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,9]]},"abstract":"Abstract<\/jats:title>\n At present, there are no hardware or biochemical systems that allow to assess the severity of post-COVID syndrome in vivo. The hardware of the proposed biotechnical system is based on routine transthoracic electrical impedance rheography, which makes it possible to register the frequency characteristics of the patient's bioimpedance response to controlled stress stimulation, thereby simultaneously fixing the characteristics of his productive heart, the state of the hemomicrocirculatory bed, the efficiency of the gas transport function of his blood, and also reliably assess personal reactivity and adaptive potential. Subsequent mathematical approximation of the obtained biometric data by an original neural network makes it possible to rank the results obtained and automatically generate a program of medical rehabilitation for a particular patient, depending on the severity of his post-COVID syndrome. The study results proved two reliable physiological signs confirming the presence of latent post-COVID complications: a decrease in the base impedance value for light exercise and an increase in the length of the systolic arc of the rheocardiogram.<\/jats:p>","DOI":"10.2478\/joeb-2022-0008","type":"journal-article","created":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T13:48:35Z","timestamp":1662644915000},"page":"45-53","source":"Crossref","is-referenced-by-count":0,"title":["Comprehensive biotechnical system for screening risk-based diagnosis of COVID-19 and post-COVID syndrome"],"prefix":"10.2478","volume":"13","author":[{"given":"Vladimir","family":"Savostyanov","sequence":"first","affiliation":[{"name":"Faculty of Biomedical Engineering, Bauman Moscow State Technical University , Moscow , Russia"}]},{"given":"Alexander","family":"Kobelev","sequence":"additional","affiliation":[{"name":"Faculty of Biomedical Engineering, Bauman Moscow State Technical University , Moscow , Russia"}]},{"given":"Ivan","family":"Kudashov","sequence":"additional","affiliation":[{"name":"Faculty of Biomedical Engineering, Bauman Moscow State Technical University , Moscow , Russia"}]}],"member":"374","published-online":{"date-parts":[[2022,9,9]]},"reference":[{"key":"2023011404180450103_j_joeb-2022-0008_ref_001","doi-asserted-by":"crossref","unstructured":"Garrigues E, Janvier P, Kherabi Y, Le Bot A, Hamon A, Gouze H et al. Post-discharge persistent symptoms and health-related quality of life after hospitalization for COVID-19. Journal of Infection. 2020;81(6):e4-e6. DOI: 10.1016\/j.jinf.2020.08.029.","DOI":"10.1016\/j.jinf.2020.08.029"},{"key":"2023011404180450103_j_joeb-2022-0008_ref_002","doi-asserted-by":"crossref","unstructured":"Carf\u00ec A, Bernabei R, Landi F. Persistent Symptoms in Patients After Acute COVID-19. JAMA. 2020;324(6):603. DOI: 10.1001\/jama.2020.12603.","DOI":"10.1001\/jama.2020.12603"},{"key":"2023011404180450103_j_joeb-2022-0008_ref_003","doi-asserted-by":"crossref","unstructured":"Tenforde M, Kim S, Lindsell C, Billig Rose E, Shapiro N, Files D et al. Symptom Duration and Risk Factors for Delayed Return to Usual Health Among Outpatients with COVID-19 in a Multistate Health Care Systems Network \u2014 United States, March\u2013June 2020. MMWR Morbidity and Mortality Weekly Report. 2020;69(30):993-998. DOI: 10.15585\/mmwr.mm6930e1.","DOI":"10.15585\/mmwr.mm6930e1"},{"key":"2023011404180450103_j_joeb-2022-0008_ref_004","doi-asserted-by":"crossref","unstructured":"Carvalho-Schneider C, Laurent E, Lemaignen A, Beaufils E, Bourbao-Tournois C, Laribi S et al. Follow-up of adults with noncritical COVID-19 two months after symptom onset. Clinical Microbiology and Infection. 2021;27(2):258-263. DOI: 10.1016\/j.cmi.2020.09.052.","DOI":"10.1016\/j.cmi.2020.09.052"},{"key":"2023011404180450103_j_joeb-2022-0008_ref_005","doi-asserted-by":"crossref","unstructured":"Van den Borst B, Peters J, Brink M, Schoon Y, Bleeker-Rovers C, Schers H et al. Comprehensive Health Assessment 3 Months After Recovery From Acute Coronavirus Disease 2019 (COVID-19). Clinical Infectious Diseases. 2020;73(5):e1089-e1098. DOI: 10.1093\/CID\/ciaa1750.","DOI":"10.1093\/cid\/ciaa1750"},{"key":"2023011404180450103_j_joeb-2022-0008_ref_006","doi-asserted-by":"crossref","unstructured":"Alexeeva N, Sokolov D, Nikityuk D, Klochkova S, Kvaratskheliya A. Molecular and cellular mechanisms of central nervous system alteration in COVID-19. Journal of Anatomy and Histopathology. 2020;9(3):72-85. DOI: 10.18499\/2225-7357-2020-9-3-72-85.","DOI":"10.18499\/2225-7357-2020-9-3-72-85"},{"key":"2023011404180450103_j_joeb-2022-0008_ref_007","doi-asserted-by":"crossref","unstructured":"Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. The Lancet. 2020;395(10229):1054-1062. DOI: 10.1016\/S0140-6736(20)30566-3","DOI":"10.1016\/S0140-6736(20)30566-3"},{"key":"2023011404180450103_j_joeb-2022-0008_ref_008","doi-asserted-by":"crossref","unstructured":"Wang Z, Yang Y, Liang X, Gao B, Liu M, Li W et al. COVID-19 Associated Ischemic Stroke and Hemorrhagic Stroke: Incidence, Potential Pathological Mechanism, and Management. Frontiers in Neurology. 2020;11. DOI: 10.3389\/fneur.2020.571996.","DOI":"10.3389\/fneur.2020.571996"},{"key":"2023011404180450103_j_joeb-2022-0008_ref_009","doi-asserted-by":"crossref","unstructured":"Magoon R. Pulmonary vasculature in COVID-19: mechanism to monitoring!. Korean Journal of Anesthesiology. 2021;74(2):186-187. DOI: 10.4097\/kja.20536.","DOI":"10.4097\/kja.20536"},{"key":"2023011404180450103_j_joeb-2022-0008_ref_010","doi-asserted-by":"crossref","unstructured":"Pinna P, Grewal P, Hall J, Tavarez T, Dafer R, Garg R et al. Neurological manifestations and COVID-19: Experiences from a tertiary care center at the Frontline. Journal of the Neurological Sciences. 2020;415:116969. DOI: 10.1016\/j.jns.2020.116969.","DOI":"10.1016\/j.jns.2020.116969"},{"key":"2023011404180450103_j_joeb-2022-0008_ref_011","doi-asserted-by":"crossref","unstructured":"Khasanova D, Zhitkova Y, Vaskaeva G. Post-covid syndrome: a review of pathophysiology, neuropsychiatric manifestations and treatment perspectives. Neurology, Neuropsychiatry, Psychosomatics. 2021;13(3):93-98. DOI: 10.14412\/2074-2711-2021-3-93-98.","DOI":"10.14412\/2074-2711-2021-3-93-98"},{"key":"2023011404180450103_j_joeb-2022-0008_ref_012","unstructured":"American National Standard Diagnostic electrocardiographic devices; ANSI\/AAMI EC11:1991\/(R)2001."},{"key":"2023011404180450103_j_joeb-2022-0008_ref_013","unstructured":"International Electrotechnical Commission [Internet]. Webstore.iec.ch. [cited 23 October 2021]. Available from: https:\/\/webstore.iec.ch\/"},{"key":"2023011404180450103_j_joeb-2022-0008_ref_014","doi-asserted-by":"crossref","unstructured":"Grimnes S, Martinsen \u00d8.G. Bioelectricity and bioimpedance basics. 2nd ed. London: Academic Press; 2008.","DOI":"10.1016\/B978-0-12-374004-5.00003-9"},{"key":"2023011404180450103_j_joeb-2022-0008_ref_015","doi-asserted-by":"crossref","unstructured":"Prutchi D, Norris M. Design and development of medical electronic instrumentation: a practical perspective of the design, construction, and test of material devices. New Jersey: John Wiley & Sons; 2005.","DOI":"10.1002\/0471681849"},{"key":"2023011404180450103_j_joeb-2022-0008_ref_016","doi-asserted-by":"crossref","unstructured":"Bour J, Kellett J. Impedance cardiography \u2014 A rapid and cost-effective screening tool for cardiac disease. European Journal of Internal Medicine. 2008;19(6):399-405. DOI: 10.1016\/j.ejim.2007.07.007.","DOI":"10.1016\/j.ejim.2007.07.007"},{"key":"2023011404180450103_j_joeb-2022-0008_ref_017","unstructured":"Babu J, Jindal GD, Bhuta AC, Parulkar GB. Impedance plethysmography: basic principles. Journal of Postgraduate Medicine. 1990;36(2): 57\u201363."},{"key":"2023011404180450103_j_joeb-2022-0008_ref_018","unstructured":"Love S, Chalmers K, Ince P, Esiri M, Attems J, Jellinger K et al. Development, appraisal, validation and implementation of a consensus protocol for the assessment of cerebral amyloid angiopathy in post-mortem brain tissue. American Journal of Neurodegenerative Disease. 2014; 3(1):19-32."},{"key":"2023011404180450103_j_joeb-2022-0008_ref_019","doi-asserted-by":"crossref","unstructured":"Naughton S, Raval U, Pasinetti G. Potential Novel Role of COVID-19 in Alzheimer\u2019s Disease and Preventative Mitigation Strategies. Journal of Alzheimer's Disease. 2020;76(1):21-25. DOI: 10.3233\/JAD-200537.","DOI":"10.3233\/JAD-200537"},{"key":"2023011404180450103_j_joeb-2022-0008_ref_020","doi-asserted-by":"crossref","unstructured":"Kumari P, Rothan H, Natekar J, Stone S, Pathak H, Strate P et al. Neuroinvasion and Encephalitis Following Intranasal Inoculation of SARS-CoV-2 in K18-hACE2 Mice. Viruses. 2021;13(1):132. DOI: 10.3390\/v13010132.","DOI":"10.3390\/v13010132"},{"key":"2023011404180450103_j_joeb-2022-0008_ref_021","doi-asserted-by":"crossref","unstructured":"Rogers J, Chesney E, Oliver D, Pollak T, McGuire P, Fusar-Poli P et al. Psychiatric and neuropsychiatric presentations associated with severe coronavirus infections: a systematic review and meta-analysis with comparison to the COVID-19 pandemic. The Lancet Psychiatry. 2020;7(7):611-627. DOI: 10.1016\/S2215-0366(20)30203-0.","DOI":"10.1016\/S2215-0366(20)30203-0"},{"key":"2023011404180450103_j_joeb-2022-0008_ref_022","doi-asserted-by":"crossref","unstructured":"Erausquin G, Snyder H, Carrillo M, Hosseini A, Brugha T, Seshadri S. The chronic neuropsychiatric sequelae of COVID\u2010 19: The need for a prospective study of viral impact on brain functioning. Alzheimer's and Dementia. 2021;17(6):10561065. DOI: 10.1002\/alz.12255.","DOI":"10.1002\/alz.12255"},{"key":"2023011404180450103_j_joeb-2022-0008_ref_023","doi-asserted-by":"crossref","unstructured":"Shi J, Gao Y, Zhao L, Li Y, Yan M, Niu M et al. Prevalence of delirium, depression, anxiety, and post-traumatic stress disorder among COVID-19 patients: protocol for a living systematic review. Systematic Reviews. 2020;9(1). DOI: 10.1186\/s13643-020-01507-2.","DOI":"10.1186\/s13643-020-01507-2"},{"key":"2023011404180450103_j_joeb-2022-0008_ref_024","doi-asserted-by":"crossref","unstructured":"Barker-Davies R, O'Sullivan O, Senaratne K, Baker P, Cranley M, Dharm-Datta S et al. The Stanford Hall consensus statement for post-COVID-19 rehabilitation. British Journal of Sports Medicine. 2020;54(16):949-959. DOI: 10.1136\/bjsports-2020-102596.","DOI":"10.1136\/bjsports-2020-102596"},{"key":"2023011404180450103_j_joeb-2022-0008_ref_025","doi-asserted-by":"crossref","unstructured":"Chernukh A, Alexandrov P, Alekseev O. Microcirculation. 2nd ed. Moscow: Medicine; 1984.","DOI":"10.1007\/978-1-4757-1824-9_41"},{"key":"2023011404180450103_j_joeb-2022-0008_ref_026","doi-asserted-by":"crossref","unstructured":"Miners S, Kehoe P, Love S. Cognitive impact of COVID-19: looking beyond the short term. Alzheimer's Research and Therapy. 2020;12(1). DOI: 10.1186\/s13195-020-00744-w.","DOI":"10.1186\/s13195-020-00744-w"},{"key":"2023011404180450103_j_joeb-2022-0008_ref_027","doi-asserted-by":"crossref","unstructured":"Beaud V, Crottaz-Herbette S, Dunet V, Vaucher J, Bernard-Valnet R, Du Pasquier R et al. Pattern of cognitive deficits in severe COVID-19. Journal of Neurology, Neurosurgery and Psychiatry. 2020;92(5):567-568. DOI: 10.1136\/jnnp-2020-325173.","DOI":"10.1136\/jnnp-2020-325173"},{"key":"2023011404180450103_j_joeb-2022-0008_ref_028","doi-asserted-by":"crossref","unstructured":"Demeco A, Marotta N, Barletta M, Pino I, Marinaro C, Petraroli A et al. Rehabilitation of patients post-COVID-19 infection: a literature review. Journal of International Medical Research. 2020;48(8). DOI: 10.1177\/0300060520948382.","DOI":"10.1177\/0300060520948382"},{"key":"2023011404180450103_j_joeb-2022-0008_ref_029","unstructured":"Smirnov VM. Human physiology. Moscow: Medicine; 2002."}],"container-title":["Journal of Electrical Bioimpedance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.sciendo.com\/pdf\/10.2478\/joeb-2022-0008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,14]],"date-time":"2023-01-14T04:20:58Z","timestamp":1673670058000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.sciendo.com\/article\/10.2478\/joeb-2022-0008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,1]]},"references-count":29,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,9,9]]},"published-print":{"date-parts":[[2022,9,9]]}},"alternative-id":["10.2478\/joeb-2022-0008"],"URL":"http:\/\/dx.doi.org\/10.2478\/joeb-2022-0008","relation":{},"ISSN":["1891-5469"],"issn-type":[{"value":"1891-5469","type":"electronic"}],"subject":["Biomedical Engineering","Biophysics"],"published":{"date-parts":[[2022,1,1]]}}} {"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,1,15]],"date-time":"2023-01-15T06:14:14Z","timestamp":1673763254764},"reference-count":29,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,9]]},"abstract":"Abstract\n At present, there are no hardware or biochemical systems that allow to assess the severity of post-COVID syndrome in vivo. The hardware of the proposed biotechnical system is based on routine transthoracic electrical impedance rheography, which makes it possible to register the frequency characteristics of the patient's bioimpedance response to controlled stress stimulation, thereby simultaneously fixing the characteristics of his productive heart, the state of the hemomicrocirculatory bed, the efficiency of the gas transport function of his blood, and also reliably assess personal reactivity and adaptive potential. Subsequent mathematical approximation of the obtained biometric data by an original neural network makes it possible to rank the results obtained and automatically generate a program of medical rehabilitation for a particular patient, depending on the severity of his post-COVID syndrome. The study results proved two reliable physiological signs confirming the presence of latent post-COVID complications: a decrease in the base impedance value for light exercise and an increase in the length of the systolic arc of the rheocardiogram.","DOI":"10.2478\/joeb-2022-0008","type":"journal-article","created":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T13:48:35Z","timestamp":1662644915000},"page":"45-53","source":"Crossref","is-referenced-by-count":0,"title":["Comprehensive biotechnical system for screening risk-based diagnosis of COVID-19 and post-COVID syndrome"],"prefix":"10.2478","volume":"13","author":[{"given":"Vladimir","family":"Savostyanov","sequence":"first","affiliation":[{"name":"Faculty of Biomedical Engineering, Bauman Moscow State Technical University , Moscow , Russia"}]},{"given":"Alexander","family":"Kobelev","sequence":"additional","affiliation":[{"name":"Faculty of Biomedical Engineering, Bauman Moscow State Technical University , Moscow , Russia"}]},{"given":"Ivan","family":"Kudashov","sequence":"additional","affiliation":[{"name":"Faculty of Biomedical Engineering, Bauman Moscow State Technical University , Moscow , Russia"}]}],"member":"374","published-online":{"date-parts":[[2022,9,9]]},"reference":[{"key":"2023011404180450103_j_joeb-2022-0008_ref_001","doi-asserted-by":"crossref","unstructured":"Garrigues E, Janvier P, Kherabi Y, Le Bot A, Hamon A, Gouze H et al. Post-discharge persistent symptoms and health-related quality of life after hospitalization for COVID-19. Journal of Infection. 2020;81(6):e4-e6. DOI: 10.1016\/j.jinf.2020.08.029.","DOI":"10.1016\/j.jinf.2020.08.029"},{"key":"2023011404180450103_j_joeb-2022-0008_ref_002","doi-asserted-by":"crossref","unstructured":"Carf\u00ec A, Bernabei R, Landi F. Persistent Symptoms in Patients After Acute COVID-19. JAMA. 2020;324(6):603. DOI: 10.1001\/jama.2020.12603.","DOI":"10.1001\/jama.2020.12603"},{"key":"2023011404180450103_j_joeb-2022-0008_ref_003","doi-asserted-by":"crossref","unstructured":"Tenforde M, Kim S, Lindsell C, Billig Rose E, Shapiro N, Files D et al. Symptom Duration and Risk Factors for Delayed Return to Usual Health Among Outpatients with COVID-19 in a Multistate Health Care Systems Network \u2014 United States, March\u2013June 2020. MMWR Morbidity and Mortality Weekly Report. 2020;69(30):993-998. DOI: 10.15585\/mmwr.mm6930e1.","DOI":"10.15585\/mmwr.mm6930e1"},{"key":"2023011404180450103_j_joeb-2022-0008_ref_004","doi-asserted-by":"crossref","unstructured":"Carvalho-Schneider C, Laurent E, Lemaignen A, Beaufils E, Bourbao-Tournois C, Laribi S et al. Follow-up of adults with noncritical COVID-19 two months after symptom onset. Clinical Microbiology and Infection. 2021;27(2):258-263. DOI: 10.1016\/j.cmi.2020.09.052.","DOI":"10.1016\/j.cmi.2020.09.052"},{"key":"2023011404180450103_j_joeb-2022-0008_ref_005","doi-asserted-by":"crossref","unstructured":"Van den Borst B, Peters J, Brink M, Schoon Y, Bleeker-Rovers C, Schers H et al. Comprehensive Health Assessment 3 Months After Recovery From Acute Coronavirus Disease 2019 (COVID-19). Clinical Infectious Diseases. 2020;73(5):e1089-e1098. DOI: 10.1093\/CID\/ciaa1750.","DOI":"10.1093\/cid\/ciaa1750"},{"key":"2023011404180450103_j_joeb-2022-0008_ref_006","doi-asserted-by":"crossref","unstructured":"Alexeeva N, Sokolov D, Nikityuk D, Klochkova S, Kvaratskheliya A. Molecular and cellular mechanisms of central nervous system alteration in COVID-19. Journal of Anatomy and Histopathology. 2020;9(3):72-85. DOI: 10.18499\/2225-7357-2020-9-3-72-85.","DOI":"10.18499\/2225-7357-2020-9-3-72-85"},{"key":"2023011404180450103_j_joeb-2022-0008_ref_007","doi-asserted-by":"crossref","unstructured":"Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. The Lancet. 2020;395(10229):1054-1062. DOI: 10.1016\/S0140-6736(20)30566-3","DOI":"10.1016\/S0140-6736(20)30566-3"},{"key":"2023011404180450103_j_joeb-2022-0008_ref_008","doi-asserted-by":"crossref","unstructured":"Wang Z, Yang Y, Liang X, Gao B, Liu M, Li W et al. COVID-19 Associated Ischemic Stroke and Hemorrhagic Stroke: Incidence, Potential Pathological Mechanism, and Management. Frontiers in Neurology. 2020;11. DOI: 10.3389\/fneur.2020.571996.","DOI":"10.3389\/fneur.2020.571996"},{"key":"2023011404180450103_j_joeb-2022-0008_ref_009","doi-asserted-by":"crossref","unstructured":"Magoon R. Pulmonary vasculature in COVID-19: mechanism to monitoring!. Korean Journal of Anesthesiology. 2021;74(2):186-187. DOI: 10.4097\/kja.20536.","DOI":"10.4097\/kja.20536"},{"key":"2023011404180450103_j_joeb-2022-0008_ref_010","doi-asserted-by":"crossref","unstructured":"Pinna P, Grewal P, Hall J, Tavarez T, Dafer R, Garg R et al. Neurological manifestations and COVID-19: Experiences from a tertiary care center at the Frontline. Journal of the Neurological Sciences. 2020;415:116969. DOI: 10.1016\/j.jns.2020.116969.","DOI":"10.1016\/j.jns.2020.116969"},{"key":"2023011404180450103_j_joeb-2022-0008_ref_011","doi-asserted-by":"crossref","unstructured":"Khasanova D, Zhitkova Y, Vaskaeva G. Post-covid syndrome: a review of pathophysiology, neuropsychiatric manifestations and treatment perspectives. Neurology, Neuropsychiatry, Psychosomatics. 2021;13(3):93-98. DOI: 10.14412\/2074-2711-2021-3-93-98.","DOI":"10.14412\/2074-2711-2021-3-93-98"},{"key":"2023011404180450103_j_joeb-2022-0008_ref_012","unstructured":"American National Standard Diagnostic electrocardiographic devices; ANSI\/AAMI EC11:1991\/(R)2001."},{"key":"2023011404180450103_j_joeb-2022-0008_ref_013","unstructured":"International Electrotechnical Commission [Internet]. Webstore.iec.ch. [cited 23 October 2021]. Available from: https:\/\/webstore.iec.ch\/"},{"key":"2023011404180450103_j_joeb-2022-0008_ref_014","doi-asserted-by":"crossref","unstructured":"Grimnes S, Martinsen \u00d8.G. Bioelectricity and bioimpedance basics. 2nd ed. London: Academic Press; 2008.","DOI":"10.1016\/B978-0-12-374004-5.00003-9"},{"key":"2023011404180450103_j_joeb-2022-0008_ref_015","doi-asserted-by":"crossref","unstructured":"Prutchi D, Norris M. Design and development of medical electronic instrumentation: a practical perspective of the design, construction, and test of material devices. New Jersey: John Wiley & Sons; 2005.","DOI":"10.1002\/0471681849"},{"key":"2023011404180450103_j_joeb-2022-0008_ref_016","doi-asserted-by":"crossref","unstructured":"Bour J, Kellett J. Impedance cardiography \u2014 A rapid and cost-effective screening tool for cardiac disease. European Journal of Internal Medicine. 2008;19(6):399-405. DOI: 10.1016\/j.ejim.2007.07.007.","DOI":"10.1016\/j.ejim.2007.07.007"},{"key":"2023011404180450103_j_joeb-2022-0008_ref_017","unstructured":"Babu J, Jindal GD, Bhuta AC, Parulkar GB. Impedance plethysmography: basic principles. Journal of Postgraduate Medicine. 1990;36(2): 57\u201363."},{"key":"2023011404180450103_j_joeb-2022-0008_ref_018","unstructured":"Love S, Chalmers K, Ince P, Esiri M, Attems J, Jellinger K et al. Development, appraisal, validation and implementation of a consensus protocol for the assessment of cerebral amyloid angiopathy in post-mortem brain tissue. American Journal of Neurodegenerative Disease. 2014; 3(1):19-32."},{"key":"2023011404180450103_j_joeb-2022-0008_ref_019","doi-asserted-by":"crossref","unstructured":"Naughton S, Raval U, Pasinetti G. Potential Novel Role of COVID-19 in Alzheimer\u2019s Disease and Preventative Mitigation Strategies. Journal of Alzheimer's Disease. 2020;76(1):21-25. DOI: 10.3233\/JAD-200537.","DOI":"10.3233\/JAD-200537"},{"key":"2023011404180450103_j_joeb-2022-0008_ref_020","doi-asserted-by":"crossref","unstructured":"Kumari P, Rothan H, Natekar J, Stone S, Pathak H, Strate P et al. Neuroinvasion and Encephalitis Following Intranasal Inoculation of SARS-CoV-2 in K18-hACE2 Mice. Viruses. 2021;13(1):132. DOI: 10.3390\/v13010132.","DOI":"10.3390\/v13010132"},{"key":"2023011404180450103_j_joeb-2022-0008_ref_021","doi-asserted-by":"crossref","unstructured":"Rogers J, Chesney E, Oliver D, Pollak T, McGuire P, Fusar-Poli P et al. Psychiatric and neuropsychiatric presentations associated with severe coronavirus infections: a systematic review and meta-analysis with comparison to the COVID-19 pandemic. The Lancet Psychiatry. 2020;7(7):611-627. DOI: 10.1016\/S2215-0366(20)30203-0.","DOI":"10.1016\/S2215-0366(20)30203-0"},{"key":"2023011404180450103_j_joeb-2022-0008_ref_022","doi-asserted-by":"crossref","unstructured":"Erausquin G, Snyder H, Carrillo M, Hosseini A, Brugha T, Seshadri S. The chronic neuropsychiatric sequelae of COVID\u2010 19: The need for a prospective study of viral impact on brain functioning. Alzheimer's and Dementia. 2021;17(6):10561065. DOI: 10.1002\/alz.12255.","DOI":"10.1002\/alz.12255"},{"key":"2023011404180450103_j_joeb-2022-0008_ref_023","doi-asserted-by":"crossref","unstructured":"Shi J, Gao Y, Zhao L, Li Y, Yan M, Niu M et al. Prevalence of delirium, depression, anxiety, and post-traumatic stress disorder among COVID-19 patients: protocol for a living systematic review. Systematic Reviews. 2020;9(1). DOI: 10.1186\/s13643-020-01507-2.","DOI":"10.1186\/s13643-020-01507-2"},{"key":"2023011404180450103_j_joeb-2022-0008_ref_024","doi-asserted-by":"crossref","unstructured":"Barker-Davies R, O'Sullivan O, Senaratne K, Baker P, Cranley M, Dharm-Datta S et al. The Stanford Hall consensus statement for post-COVID-19 rehabilitation. British Journal of Sports Medicine. 2020;54(16):949-959. DOI: 10.1136\/bjsports-2020-102596.","DOI":"10.1136\/bjsports-2020-102596"},{"key":"2023011404180450103_j_joeb-2022-0008_ref_025","doi-asserted-by":"crossref","unstructured":"Chernukh A, Alexandrov P, Alekseev O. Microcirculation. 2nd ed. Moscow: Medicine; 1984.","DOI":"10.1007\/978-1-4757-1824-9_41"},{"key":"2023011404180450103_j_joeb-2022-0008_ref_026","doi-asserted-by":"crossref","unstructured":"Miners S, Kehoe P, Love S. Cognitive impact of COVID-19: looking beyond the short term. Alzheimer's Research and Therapy. 2020;12(1). DOI: 10.1186\/s13195-020-00744-w.","DOI":"10.1186\/s13195-020-00744-w"},{"key":"2023011404180450103_j_joeb-2022-0008_ref_027","doi-asserted-by":"crossref","unstructured":"Beaud V, Crottaz-Herbette S, Dunet V, Vaucher J, Bernard-Valnet R, Du Pasquier R et al. Pattern of cognitive deficits in severe COVID-19. Journal of Neurology, Neurosurgery and Psychiatry. 2020;92(5):567-568. DOI: 10.1136\/jnnp-2020-325173.","DOI":"10.1136\/jnnp-2020-325173"},{"key":"2023011404180450103_j_joeb-2022-0008_ref_028","doi-asserted-by":"crossref","unstructured":"Demeco A, Marotta N, Barletta M, Pino I, Marinaro C, Petraroli A et al. Rehabilitation of patients post-COVID-19 infection: a literature review. Journal of International Medical Research. 2020;48(8). DOI: 10.1177\/0300060520948382.","DOI":"10.1177\/0300060520948382"},{"key":"2023011404180450103_j_joeb-2022-0008_ref_029","unstructured":"Smirnov VM. Human physiology. Moscow: Medicine; 2002."}],"container-title":["Journal of Electrical Bioimpedance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.sciendo.com\/pdf\/10.2478\/joeb-2022-0008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,14]],"date-time":"2023-01-14T04:20:58Z","timestamp":1673670058000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.sciendo.com\/article\/10.2478\/joeb-2022-0008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,1]]},"references-count":29,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,9,9]]},"published-print":{"date-parts":[[2022,9,9]]}},"alternative-id":["10.2478\/joeb-2022-0008"],"URL":"http:\/\/dx.doi.org\/10.2478\/joeb-2022-0008","relation":{},"ISSN":["1891-5469"],"issn-type":[{"value":"1891-5469","type":"electronic"}],"subject":["Biomedical Engineering","Biophysics"],"published":{"date-parts":[[2022,1,1]]}}}

DOI: 10.2478/joeb-2022-0008

Abstract

At present, there are no hardware or biochemical systems allow to assess the severity of post-COVID syndrome in vivo. The hardware of the proposed biotechnical system is based on routine transthoracic electrical impedance rheography, which makes it possible to register the frequency characteristics of the patient's bioimpedance response to controlled stress stimulation, thereby simultaneously fixing the characteristics of his productive heart, the state of the hemomicrocirculatory bed, the efficiency of the gas transport function of his blood, and also reliably assess personal reactivity and adaptive potential. Subsequent mathematical approximation of the obtained biometric data by an original neural network makes it possible to rank the results obtained and automatically generate a program of medical rehabilitation for a particular patient, depending on the severity of his post-COVID syndrome. The study results proved two reliable physiological signs confirming the presence of latent post-COVID complications: a decrease in the base impedance value for light exercise and an increase in the length of the systolic arc of the rheocardiogram.

Keywords

Bioimpedance; COVID-19; E-health; Health Care Personnel; Pathophysiology; Post-COVID syndrome; Rheography

Subject

MEDICINE & PHARMACOLOGY, Pathology & Pathobiology

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.