Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Association Between Systemic Arterial Hypertension with Laboratory Markers, Body Composition, Obstructive Sleep Apnea and Heart Rate Variability in Obese Adults

Version 1 : Received: 8 May 2022 / Approved: 10 May 2022 / Online: 10 May 2022 (04:45:21 CEST)

How to cite: Santos, C.; Lagares, L.; Santos, S.; Santos, F.; Silva, M.; Macedo, R.; Almeida, L.; Bomfim, E. Association Between Systemic Arterial Hypertension with Laboratory Markers, Body Composition, Obstructive Sleep Apnea and Heart Rate Variability in Obese Adults. Preprints 2022, 2022050127 (doi: 10.20944/preprints202205.0127.v1). Santos, C.; Lagares, L.; Santos, S.; Santos, F.; Silva, M.; Macedo, R.; Almeida, L.; Bomfim, E. Association Between Systemic Arterial Hypertension with Laboratory Markers, Body Composition, Obstructive Sleep Apnea and Heart Rate Variability in Obese Adults. Preprints 2022, 2022050127 (doi: 10.20944/preprints202205.0127.v1).

Abstract

Background: Elevated fasting plasma glucose and visceral fat area (VFA) is highly prevalent in obese adults. This study investigated the associations between systemic arterial hypertension (SAH) and laboratory, anthropometric, heart rate variability (HRV), and obstructive sleep apnea markers. Methods: Cross-sectional study with 95 obese patients treated at Obesity Treatment and Surgery Center, located in Salvador, BA, Brazil. SAH data were obtained from electronic medical records of patients. To evaluate the association of SAH with the predictor variables, the sample was stratified in Normotense Group (NG) and Hypertensive Group (HG), and laboratory markers, body composition, polysomnography data, and HRV were measured. Results: The average age of the NG was 36.3 ± 10.1 and HG 40.4 ± 10.6 years, 73.7% were women in the NG and 57.9% in HG; 82.4% in HG had insulin resistance. In the multivarious logistics regression model with adjustments age, sex, height, and oxyhemoglobin saturation, SAH was inversely associated with fasting plasma glucose mg/dL (odds ratio [OR] = 0.96; 95% interval confidence [CI] = 0.92 - 0.99) and VFA cm2 (OR = 0.98; 95% CI = 0.97 - 0.99). The area under curve the VFA was 0.728; CI 95% (0.620 - 0.836) and fasting plasma glucose 0.693; CI 95% (0.582 - 0.804). Conclusions: Lower VFA and fasting plasma glucose concentrations were inversely associated with SAH. These results indicate opportunities to improve the outcome in obese patients through counseling and clinical interventions.

Keywords

hypertension; obesity; body composition; intra-abdominal fat; sleep apnea; obstructive

Subject

MEDICINE & PHARMACOLOGY, Pathology & Pathobiology

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