Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Blood Biomarkers for Triaging Young Adults and Children for a Suspected Stroke: Every Minute Counts

Version 1 : Received: 28 April 2022 / Approved: 29 April 2022 / Online: 29 April 2022 (07:44:11 CEST)

A peer-reviewed article of this Preprint also exists.

Jadav, R.K.; Mortazavi, R.; Yee, K.C. Blood Biomarkers for Triaging Patients for Suspected Stroke: Every Minute Counts. J. Clin. Med. 2022, 11, 4243. Jadav, R.K.; Mortazavi, R.; Yee, K.C. Blood Biomarkers for Triaging Patients for Suspected Stroke: Every Minute Counts. J. Clin. Med. 2022, 11, 4243.

Journal reference: J. Clin. Med. 2022, 11, 4243
DOI: 10.3390/jcm11144243

Abstract

Early stroke diagnosis remains a big challenge in healthcare partly due to the lack of reliable diagnostic blood biomarkers, which in turn leads to increased rates of mortality and disability. Current screening methods are optimised to identify patients with a high risk of cardio-vascular disease, especially among the elderly. However, in young adults and children, these methods suffer low sensitivity and specificity and contribute to further delays in their triage and diagnosis. Accordingly, there is an urgent need to develop reliable blood biomarkers for triaging patients suspected of stroke in all age groups, especially children and young adults. This review explores some of the existing blood biomarkers, as single biomarkers, or biomarker panels, and examine their sensitivity and specificity for predicting stroke. A review was performed on PubMed and Web of Science for journal articles published in English during the period 2001 to 2021 which contained information regarding biomarkers of stroke. In this review article, we provide comparative information on the availability, clinical usefulness, and time-window periods of eight single blood biomarkers and six biomarker panels that have been used for predicting stroke in emergency situations. The outcomes of this review can be used in future research for developing more effective stroke biomarkers.

Keywords

stroke; CNS; ischaemic; haemorrhagic; biomarker; panel; young adults; children; triage; specifici-ty; sensitivity; prediction values

Subject

MEDICINE & PHARMACOLOGY, Clinical Neurology

Comments (1)

Comment 1
Received: 3 August 2022
Commenter:
The commenter has declared there is no conflict of interests.
Comment: Please check out the peer-reviewed version on the journal's website.
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