Version 1
: Received: 25 April 2022 / Approved: 25 April 2022 / Online: 25 April 2022 (10:22:39 CEST)
How to cite:
Rawat, K.; Syeda, S.; Shrivastava, A. A Novel Role of Tinospora Cordifolia inAmelioration of Cancer-Induced Systemic Deterioration By Taming Neutrophil Infiltration and Hyperactivation. Preprints2022, 2022040222. https://doi.org/10.20944/preprints202204.0222.v1
Rawat, K.; Syeda, S.; Shrivastava, A. A Novel Role of Tinospora Cordifolia in Amelioration of Cancer-Induced Systemic Deterioration By Taming Neutrophil Infiltration and Hyperactivation. Preprints 2022, 2022040222. https://doi.org/10.20944/preprints202204.0222.v1
Rawat, K.; Syeda, S.; Shrivastava, A. A Novel Role of Tinospora Cordifolia inAmelioration of Cancer-Induced Systemic Deterioration By Taming Neutrophil Infiltration and Hyperactivation. Preprints2022, 2022040222. https://doi.org/10.20944/preprints202204.0222.v1
APA Style
Rawat, K., Syeda, S., & Shrivastava, A. (2022). A Novel Role of <i>Tinospora Cordifolia </i>in<i> </i>Amelioration of Cancer-Induced Systemic Deterioration By Taming Neutrophil Infiltration and Hyperactivation. Preprints. https://doi.org/10.20944/preprints202204.0222.v1
Chicago/Turabian Style
Rawat, K., Saima Syeda and Anju Shrivastava. 2022 "A Novel Role of <i>Tinospora Cordifolia </i>in<i> </i>Amelioration of Cancer-Induced Systemic Deterioration By Taming Neutrophil Infiltration and Hyperactivation" Preprints. https://doi.org/10.20944/preprints202204.0222.v1
Abstract
Cancer has emerged as a systemic disease which targets various organs thus challenging the overall physiology of the host. Recently, we have shown that hyperactive neutrophils infiltrate various organs of tumor bearing host and contribute significantly to gradual systemic deterioration. Therefore, taming neutrophils via potent immunomodulators could be an appropriate therapeutic approach in regulating systemic damage. Tinosporacordifolia (TC), an Ayurvedic panacea, is known for its immense medicinal values in traditional literature and recent reports have also documented its strong immunomodulatory potential. However, whether TC can regulate neutrophils to exert its therapeutic effectiveness has not been deciphered so far. To discern this, we utilized murine model of Dalton’s Lymphoma (DL) wherein, we have earlier reported heightened infiltration of neutrophils and their hyperactivation. Our findings showed that TC treatment significantly reduced neutrophil count in peripheral blood and their infiltration in vital organs of tumor bearing host. Further, it ameliorated neutrophil hyperactivation by down regulating the expression of its key cargoes including neutrophil elastase (NE), myeloperoxidase (MPO), MMP-8, MMP-9 and cathepsin G (CSTG) at early and mid stage of tumor growth. In addition, TC treatment prevented histopathological alterations and restored the normal serum enzyme levels at different stages of tumor growth. Importantly, TC treatment also showed significant reduction in tumor burden which was accompanied by a remarkable increase in survival of the tumor-bearing mice. We conclude that Tinospora cordifolia could limit systemic damage via regulating neutrophil infiltration and hyperactivation which can further lead to cancer control at both prophylactic and therapeutic level.
Keywords
Tinospora cordifolia; Neutrophils; Systemic deterioration; Hyperactivation; Granular cargoes; Immunomodulation; Cancer
Subject
Biology and Life Sciences, Immunology and Microbiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
