Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Prostate Cancer as a Channelopathy

Version 1 : Received: 20 April 2022 / Approved: 21 April 2022 / Online: 21 April 2022 (13:58:54 CEST)

How to cite: Sakellakis, M. Prostate Cancer as a Channelopathy. Preprints 2022, 2022040207 (doi: 10.20944/preprints202204.0207.v1). Sakellakis, M. Prostate Cancer as a Channelopathy. Preprints 2022, 2022040207 (doi: 10.20944/preprints202204.0207.v1).

Abstract

Numerous studies have firmly established the role of ion channels in essentially all basic cellular functions. Apart from their role in ion transport, they can form macromolecular complexes with adhesion proteins, and signaling molecules. Ion channels are not only responsible for cellular electrogenesis and excitability, but they also regulate the necessary conditions for tissue homeostasis, such as differentiation, proliferation and apoptosis. Although cancer is not officially classified as a channelopathy, it has been increasingly recognized that ion channel aberrations play an important role in virtually all cancer types. Ion channels can exert pro-tumorigenic activities due to genetic or epigenetic alterations, or as a response to molecular signals, such as growth factors, hormones, etc. Prostate cancer is the second leading cause of cancer-related death in men in the United States. Increasing evidence suggests that ion channels and pumps play a critical role in the regulation of prostate cancer cell proliferation, apoptosis evasion, migration, epithelial-to-mesenchymal transition and angiogenesis. There is also evidence suggesting that ion channels might play a role in treatment failure in prostate cancer. Hence, they represent promising targets for diagnosis, staging and treatment. Here, the role of major types of ion channels involved in the development and progression of prostate cancer were reviewed. Identifying the underlying molecular mechanisms of the pro-tumorigenic effects of ion channels, may potentially inform the development of novel therapeutic strategies to counter this malignancy.

Keywords

prostate; cancer; proliferation; ion; channels

Subject

MEDICINE & PHARMACOLOGY, Oncology & Oncogenics

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