Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Magnetoliposomes Containing Multicore Nanoparticles and a New Thienopyridine Antitumor Compound for Chemo/Thermotherapy

Version 1 : Received: 4 April 2022 / Approved: 6 April 2022 / Online: 6 April 2022 (10:27:22 CEST)

How to cite: Lopes, F.A.C.; Fernandes, A.V.F.; Rodrigues, J.M.; Queiroz, M.R.P.; Almeida, B.G.; Pires, A.; Pereira, A.M.; Araújo, J.P.; Rodrigues, A.R.O.; Castanheira, E.M.S.; Coutinho, P.J.G. Magnetoliposomes Containing Multicore Nanoparticles and a New Thienopyridine Antitumor Compound for Chemo/Thermotherapy. Preprints 2022, 2022040041 (doi: 10.20944/preprints202204.0041.v1). Lopes, F.A.C.; Fernandes, A.V.F.; Rodrigues, J.M.; Queiroz, M.R.P.; Almeida, B.G.; Pires, A.; Pereira, A.M.; Araújo, J.P.; Rodrigues, A.R.O.; Castanheira, E.M.S.; Coutinho, P.J.G. Magnetoliposomes Containing Multicore Nanoparticles and a New Thienopyridine Antitumor Compound for Chemo/Thermotherapy. Preprints 2022, 2022040041 (doi: 10.20944/preprints202204.0041.v1).

Abstract

Multicore magnetic nanoparticles of manganese ferrite were prepared using carboxymethyl-dextran and melamine as agglutinating agents. The nanoparticles prepared using melamine exhibit a flower-shape structure, a saturation magnetization of 6.16 emu/g and good capabilities for magnetic hyperthermia. Magnetoliposome-like structures containing the multicore nanoparticles exhibit sizes in the range 250 – 400 nm. A new antitumor thienopyridine derivative was loaded in these nanocarriers with a high encapsulation efficiency of 98% ± 2.6%. Release profiles in absence and presence of an AMF indicate a transport by diffusion, with a maximum compound release of 31% under the AMF. A sustained and controlled drug release in anticipated from the results, pointing to suitable characteristics of the magnetoliposomes for dual cancer therapy (combined magnetic hyperthermia and chemotherapy).

Keywords

multicore magnetic nanoparticles; magnetoliposomes; magnetic hyperthermia; antitumor thienopyridine derivative; chemotherapy

Subject

MATERIALS SCIENCE, Biomaterials

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