Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

ZIKA Virus Envelope Protein Forms Disulfide Bond-Dependent Polymers: Evidence for A Redox Imbalance during Infection

Version 1 : Received: 1 April 2022 / Approved: 6 April 2022 / Online: 6 April 2022 (05:24:41 CEST)

A peer-reviewed article of this Preprint also exists.

Lebeau, G.; Turpin, J.; Frumence, E.; El Safadi, D.; Harrabi, W.; Desprès, P.; Krejbich-Trotot, P.; Viranaïcken, W. Evidence of RedOX Imbalance during Zika Virus Infection Promoting the Formation of Disulfide-Bond-Dependent Oligomers of the Envelope Protein. Viruses 2022, 14, 1131. Lebeau, G.; Turpin, J.; Frumence, E.; El Safadi, D.; Harrabi, W.; Desprès, P.; Krejbich-Trotot, P.; Viranaïcken, W. Evidence of RedOX Imbalance during Zika Virus Infection Promoting the Formation of Disulfide-Bond-Dependent Oligomers of the Envelope Protein. Viruses 2022, 14, 1131.

Journal reference: Viruses 2022, 14, 1131
DOI: 10.3390/v14061131

Abstract

Flaviviruses replicate in membrane factories associated with the endoplasmic reticulum (ER). Significant levels of flavivirus viral protein accumulation contribute to ER stress. As a consequence, the host cell exhibits an Unfolded Protein Response (UPR), subsequently stimulating appropriate cellular responses such as adaptation, autophagy or apoptosis. The correct redox conditions of this compartment are essential to form native disulfide bonds in proteins. ZIKA virus (ZIKV) has ability to induce persistent ER stress leading to activation of UPR pathways. In this study, we wondered whether ZIKV affects the redox balance and consequently the oxidative protein folding in the ER. We found that ZIKV replication influences redox state leading to aggregation of viral envelope protein as amyloid-like structures in the infected cells.

Keywords

Zika virus; unfolded protein response; ER stress; oligomer; disulfide bond amyloid aggregates

Subject

LIFE SCIENCES, Virology

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.

We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.