Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

On the Essential Role of SARS-CoV-2 Localization in the Nasopharynx and Intestines in the Pathogenesis of COVID-19

Version 1 : Received: 27 March 2022 / Approved: 28 March 2022 / Online: 28 March 2022 (14:40:14 CEST)

How to cite: Afonyushkin, V.; Akberdin, I.; Kozlova, Y.; Shchukin, I.; Mironova, T.; Bobikova, A.; Donchenko, N.; Cherepushkina, V.; Poletaeva, Y.; Kolpakov, F. On the Essential Role of SARS-CoV-2 Localization in the Nasopharynx and Intestines in the Pathogenesis of COVID-19. Preprints 2022, 2022030369 (doi: 10.20944/preprints202203.0369.v1). Afonyushkin, V.; Akberdin, I.; Kozlova, Y.; Shchukin, I.; Mironova, T.; Bobikova, A.; Donchenko, N.; Cherepushkina, V.; Poletaeva, Y.; Kolpakov, F. On the Essential Role of SARS-CoV-2 Localization in the Nasopharynx and Intestines in the Pathogenesis of COVID-19. Preprints 2022, 2022030369 (doi: 10.20944/preprints202203.0369.v1).

Abstract

Patients with COVID-19 may develop pneumonia, severe symptoms of acute respiratory distress syndrome, and multiple organ failure. Nevertheless, the variety of forms of this disease, requires further research on the pathogenesis of this disease. Based on the analysis of published data on the concentrations of SARS-CoV-2 in biological fluids of the nasopharynx, lungs and intestines and using a developed modular model of the virus distribution in human tissue and organs, an assessment of the SARS-CoV-2 reproduction in various compartments of the body is presented. Most of viral particles can enter into the esophagus from nasopharynx. Entering viral particles into the gastrointestinal tract will obviously be accompanied by infection of the intestinal epithelium and accumulation of the virus in the intestinal lumen in an amount proportional their secretory and protein-synthetic activities. The relatively low concentration of SARS-CoV-2 in tissues implies an essential role of transport processes and redistribution of the virus from nasopharynx and intestines to lungs. The model simulations also supposes that sanitation of the nasopharynx mucosa at the initial stage of the infectious process considering inhibition of the virus accumulation by means of cellular and humoral responses has prospects for the use in medicine practice.

Keywords

SARS-CoV-2; COVID-19; immunology; nasopharynx; intestines; lungs; mathematical modeling; modular approach; pathophysiology of COVID-19

Subject

LIFE SCIENCES, Virology

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