Preprint Communication Version 1 Preserved in Portico This version is not peer-reviewed

First Molecular Identification of Three Clinical Isolates of Fungi Causing Mucormycosis in Honduras

Version 1 : Received: 23 March 2022 / Approved: 25 March 2022 / Online: 25 March 2022 (15:24:39 CET)

A peer-reviewed article of this Preprint also exists.

Ortiz, B.; Laínez-Arteaga, I.; Galindo-Morales, C.; Acevedo-Almendárez, L.; Aguilar, K.; Valladares, D.; López, M.; Fontecha, G. First Molecular Identification of Three Clinical Isolates of Fungi Causing Mucormycosis in Honduras. Infect. Dis. Rep. 2022, 14, 258-265. Ortiz, B.; Laínez-Arteaga, I.; Galindo-Morales, C.; Acevedo-Almendárez, L.; Aguilar, K.; Valladares, D.; López, M.; Fontecha, G. First Molecular Identification of Three Clinical Isolates of Fungi Causing Mucormycosis in Honduras. Infect. Dis. Rep. 2022, 14, 258-265.

Abstract

Mucormycoses are rare but serious opportunistic fungal infections caused by filamentous organisms of the order Mucorales. Here we report the first molecular identification of Rhizopus oryzae (heterotypic synonym Rhizopus arrhizus), R. delemar, and Apophysomyces ossiformis as the etiological agents of three cases of severe mucormycosis in Honduras. Conventional microbiological cultures were carried out, and DNA was extracted from both clinical samples and axenic cultures. The ITS ribosomal region was amplified and sequenced. Molecular tools are suitable strategies for diagnosing and identifying Mucorales in tissues and cultures, especially in middle-income countries lacking routine diagnostic strategies.

Keywords

Mucormycosis; Honduras; Rhizopus oryzae; Apophysomyces ossiformis

Subject

Biology and Life Sciences, Immunology and Microbiology

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