Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Immunologic and Neuroinflammatory Bases of Epileptogenesis: Personalized Therapeutic Options

Version 1 : Received: 20 February 2022 / Approved: 21 February 2022 / Online: 21 February 2022 (14:59:18 CET)

A peer-reviewed article of this Preprint also exists.

Aguilar-Castillo, M.J.; Cabezudo-García, P.; Ciano-Petersen, N.L.; García-Martin, G.; Marín-Gracia, M.; Estivill-Torrús, G.; Serrano-Castro, P.J. Immune Mechanism of Epileptogenesis and Related Therapeutic Strategies. Biomedicines 2022, 10, 716. Aguilar-Castillo, M.J.; Cabezudo-García, P.; Ciano-Petersen, N.L.; García-Martin, G.; Marín-Gracia, M.; Estivill-Torrús, G.; Serrano-Castro, P.J. Immune Mechanism of Epileptogenesis and Related Therapeutic Strategies. Biomedicines 2022, 10, 716.

Journal reference: Biomedicines 2022, 10, 716
DOI: 10.3390/biomedicines10030716

Abstract

Background: Immunologic and neuro-inflammatory pathways have been found to play a major role in the pathogenesis of many neurological disorders such as epilepsy, proposing the use of novel therapeutic strategies. In the era of personalized medicine and in the face of the exhaustion of anti-seizure therapeutic resources it is worth looking at the current or future possibilities that neuroimmunomodulator or anti-inflammatory therapy can offer us in the management of patients with epilepsy. Methods: We performed a narrative review on the recent advances on the basic epileptogenic mechanisms related to the activation of immunity or neuroinflammation with special attention to current and future opportunities for novel treatments in epilepsy. Results: Neuroinflammation can be considered a universal phenomenon and occurs in structural, infectious, post-traumatic, autoimmune, or even genetically based epilepsies. The emerging research developed in recent years has allowed us to identify the main molecular pathways in-volved in these processes. These molecular pathways could constitute future therapeutic targets for epilepsy. Conclusions: Different drugs current or in development have demonstrated their capacity to inhibit or modulate molecular pathways involved in the immunologic or neuroinflammatory mechanisms described in epilepsy. Some of them should be tested in the future as possible antiepileptic drugs.

Keywords

Epilepsy; Neuroimmunology; Neuroinflammation; Epileptogenesis; Personalized medicine

Subject

MEDICINE & PHARMACOLOGY, Clinical Neurology

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