Version 1
: Received: 8 February 2022 / Approved: 9 February 2022 / Online: 9 February 2022 (10:26:55 CET)
How to cite:
Jung, Y.S.; Choi, J.Y.; Kwon, Y.; Park, G.; Dachuri, V.; Kim, Y.W.; Ku, S.; Song, C. Anti-allergic Effects Of Fertilized Red Ginseng Marc On 2,4-dinitrochlorobenzene-induced Atopic Dermatitis-like Mice Model. Preprints2022, 2022020131. https://doi.org/10.20944/preprints202202.0131.v1
Jung, Y.S.; Choi, J.Y.; Kwon, Y.; Park, G.; Dachuri, V.; Kim, Y.W.; Ku, S.; Song, C. Anti-allergic Effects Of Fertilized Red Ginseng Marc On 2,4-dinitrochlorobenzene-induced Atopic Dermatitis-like Mice Model. Preprints 2022, 2022020131. https://doi.org/10.20944/preprints202202.0131.v1
Jung, Y.S.; Choi, J.Y.; Kwon, Y.; Park, G.; Dachuri, V.; Kim, Y.W.; Ku, S.; Song, C. Anti-allergic Effects Of Fertilized Red Ginseng Marc On 2,4-dinitrochlorobenzene-induced Atopic Dermatitis-like Mice Model. Preprints2022, 2022020131. https://doi.org/10.20944/preprints202202.0131.v1
APA Style
Jung, Y.S., Choi, J.Y., Kwon, Y., Park, G., Dachuri, V., Kim, Y.W., Ku, S., & Song, C. (2022). Anti-allergic Effects Of Fertilized Red Ginseng Marc On 2,4-dinitrochlorobenzene-induced Atopic Dermatitis-like Mice Model. Preprints. https://doi.org/10.20944/preprints202202.0131.v1
Chicago/Turabian Style
Jung, Y.S., Sae-Kwang Ku and Chang-Hyun Song. 2022 "Anti-allergic Effects Of Fertilized Red Ginseng Marc On 2,4-dinitrochlorobenzene-induced Atopic Dermatitis-like Mice Model" Preprints. https://doi.org/10.20944/preprints202202.0131.v1
Abstract
Atopic dermatitis (AD) is a chronic and allergic skin disease, however, there is no cure for the disease. Many studies have shown anti-AD potentials of red ginseng, while red ginseng marc (RGM) remained after the ginseng extraction is discarded as industrial waste. However, it is recently reported that RGM, particularly fermented RGM (fRGM), still contains the bioactive properties. Thus, anti-allergic effects of fRGM were examined in 2,4-dinitrochlorobenzene-induced AD-like mice model. The model was topically treated with distilled water (control), dexamethasone, or fRGM for six weeks. The treatments of fRGM alleviated the skin lesions and reduced serum IgE levels, compared with the control. The fRGM also reduced skin levels of lipid peroxidation and superoxide anion, however, increased glutathione contents, with down-regulated gene expressions for inflammatory mediators. The histopathological analyses demonstrated that fRGM suppressed the epidermal thickening, collagen deposition, and inflammatory cell and mast cell infiltration, which involved the anti-inflammatory, anti-oxidant, and anti-apoptotic effects. Further, fRGM suppressed hypertrophic changes and inflammatory responses in the spleen and lymph node. The beneficial effects were observed in the dexamethasone and fRGM groups, however, the antioxidant effects were evident only in the fRGM treatments. These provide useful information for developing fRGM as therapeutic sources for AD.
Keywords
AD; allergy; skin; DNCB; Panax ginseng; red ginseng marc; fermentation
Subject
Medicine and Pharmacology, Dermatology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
,
,
,
*
